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In vitro antitumor activity of silybin nanosuspension in PC-3 cells
Zheng, Dandan; Wang, Yancai; Zhang, Dianrui1; Liu, Zhaoping2; Duan, Cunxian; Jia, Lejiao; Wang, Feihu; Liu, Yue; Liu, Guangpu; Hao, Leilei; Zhang, Qiang3
关键词Silybin Nanosuspension Antitumor Cytotoxicity
刊名CANCER LETTERS
2011-08-28
DOI10.1016/j.canlet.2011.03.028
307期:2页:158-164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Basic Research Program of China (973Program) ; National Basic Research Program of China (973Program)
研究领域[WOS]Oncology
关键词[WOS]FOLLICLE-ASSOCIATED EPITHELIUM ; DELIVERY-SYSTEM ; SILIBININ ; GROWTH ; CANCER ; MODEL ; NANOPARTICLES ; FORMULATION ; INHIBITION ; SILYMARIN
英文摘要

The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2009CB 930300
资助者National Basic Research Program of China (973Program) ; National Basic Research Program of China (973Program)
WOS记录号WOS:000292351300007
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60885
专题北京大学药学院
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Ctr New Drugs Evaluat, Jinan 250012, Shandong, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Dandan,Wang, Yancai,Zhang, Dianrui,et al. In vitro antitumor activity of silybin nanosuspension in PC-3 cells[J]. CANCER LETTERS,2011,307(2):158-164.
APA Zheng, Dandan.,Wang, Yancai.,Zhang, Dianrui.,Liu, Zhaoping.,Duan, Cunxian.,...&Zhang, Qiang.(2011).In vitro antitumor activity of silybin nanosuspension in PC-3 cells.CANCER LETTERS,307(2),158-164.
MLA Zheng, Dandan,et al."In vitro antitumor activity of silybin nanosuspension in PC-3 cells".CANCER LETTERS 307.2(2011):158-164.
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