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学科主题: 药学
题名:
In vitro antitumor activity of silybin nanosuspension in PC-3 cells
作者: Zheng, Dandan; Wang, Yancai; Zhang, Dianrui1; Liu, Zhaoping2; Duan, Cunxian; Jia, Lejiao; Wang, Feihu; Liu, Yue; Liu, Guangpu; Hao, Leilei; Zhang, Qiang3
关键词: Silybin ; Nanosuspension ; Antitumor ; Cytotoxicity
刊名: CANCER LETTERS
发表日期: 2011-08-28
DOI: 10.1016/j.canlet.2011.03.028
卷: 307, 期:2, 页:158-164
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: FOLLICLE-ASSOCIATED EPITHELIUM ; DELIVERY-SYSTEM ; SILIBININ ; GROWTH ; CANCER ; MODEL ; NANOPARTICLES ; FORMULATION ; INHIBITION ; SILYMARIN
英文摘要:

The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB 930300
项目资助者: National Basic Research Program of China (973Program)
WOS记录号: WOS:000292351300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60885
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Ctr New Drugs Evaluat, Jinan 250012, Shandong, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zheng, Dandan,Wang, Yancai,Zhang, Dianrui,et al. In vitro antitumor activity of silybin nanosuspension in PC-3 cells[J]. CANCER LETTERS,2011,307(2):158-164.
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