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Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas
Luo, H. -Y.; Yu, S. -F; Li, T. -J.
关键词ameloblastoma apoptosis immunohistochemistry
刊名INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2006-08-01
DOI10.1016/j.ijom.2006.03.012
35期:8页:750-755
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]IMMUNOHISTOCHEMICAL ANALYSIS ; UNICYSTIC AMELOBLASTOMA ; DEATH ; FAS ; CASPASES ; ANTIGEN ; LIGAND ; MECHANISMS ; PATHOLOGY ; CANCER
英文摘要

To evaluate the expression patterns of apoptosis-related proteins, including Fas, Fas-ligand (FasL), caspase-3 and Bcl-2, in various cellular components of ameloblastomas, 39 cases of ameloblastoma were examined using immunohistochemistry. The staining intensity of the antigens in the 4 types of tumour cellular component, peripheral basal cells of tumour nests, central stellate reticulum-like cells, and foci of squamous and granular cells, was scored using a semi-quantitative scale, and comparisons were made by statistical analysis. Expression of Fas, FasL and caspase-3 was detected in the majority of cases, with a similar pattern of strong staining in the foci of squamous metaplasia and granular cells usually situated in the central area of tumour islands. In contrast, expression of Bcl-2 was predominantly seen in the peripheral basal cell layer. There were significant differences in the staining intensity of Fas, caspase-3 and Bcl-2 among the 4 types of tumour cell. The differential expression of apoptosis-related proteins in various cellular components of ameloblastomas, with pro-apoptotic proteins, Fas, FasL and caspase-3 being closely associated with squamous metaplasia and granular transformation of the tumour cells, suggests that Fas/FasL-induced apoptotic cell death may play a role in the disposal of terminally differentiated or degenerative tumour cells in ameloblastomas.

语种英语
WOS记录号WOS:000239030400012
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60888
专题北京大学口腔医学院_口腔病理科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
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GB/T 7714
Luo, H. -Y.,Yu, S. -F,Li, T. -J.. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2006,35(8):750-755.
APA Luo, H. -Y.,Yu, S. -F,&Li, T. -J..(2006).Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,35(8),750-755.
MLA Luo, H. -Y.,et al."Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 35.8(2006):750-755.
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