IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data
Muthuri, Stella G.1; Venkatesan, Sudhir1; Myles, Puja R.1; Leonardi-Bee, Jo1; Al Khuwaitir, Tarig S. A.2; Al Mamun, Adbullah3; Anovadiya, Ashish P.4,5; Azziz-Baumgartner, Eduardo6; Baez, Clarisa7; Bassetti, Matteo8; Beovic, Bojana9; Bertisch, Barbara10; Bonmarin, Isabelle11; Booy, Robert12; Borja-Aburto, Victor H.13; Burgmann, Heinz14; Cao, Bin15; Carratala, Jordi16; Denholm, Justin T.17,18; Dominguez, Samuel R.19; Duarte, Pericles A. D.20; Dubnov-Raz, Gal21; Echavarria, Marcela22; Fanella, Sergio23; Gao, Zhancheng24; Gerardin, Patrick25,26,27; Giannella, Maddalena28; Gubbels, Sophie29; Herberg, Jethro30; Higuera Iglesias, Anjarath L.31; Hoger, Peter H.32; Hu, Xiaoyun33; Islam, Quazi T.34; Jimenez, Mirela F.35; Kandeel, Amr36; Keijzers, Gerben37; Khalili, Hossein38; Knight, Marian39; Kudo, Koichiro40; Kusznierz, Gabriela41; Kuzman, Ilija42; Kwan, Arthur M. C.43; Amine, Idriss Lahlou44; Langenegger, Eduard45,46; Lankarani, Kamran B.47; Leo, Yee-Sin48; Linko, Rita49; Liu, Pei50; Madanat, Faris51; Mayo-Montero, Elga52; McGeer, Allison53; Memish, Ziad54,55; Metan, Gokhan56; Mickiene, Aukse57; Mikic, Dragan58; Mohn, Kristin G. I.59,60,61; Moradi, Ahmadreza62,63; Nymadawa, Pagbajabyn64; Oliva, Maria E.65; Ozkan, Mehpare66; Parekh, Dhruv67; Paul, Mical68; Polack, Fernando P.69,70; Rath, Barbara A.71; Rodriguez, Alejandro H.72; Sarrouf, Elena B.73; Seale, Anna C.74,75; Sertogullarindan, Bunyamin76; Siqueira, Marilda M.77; Skret-Magierlo, Joanna78; Stephan, Frank79; Talarek, Ewa80; Tang, Julian W.81,82,83; To, Kelvin K. W.84,85; Torres, Antoni86; Torun, Selda H.87; Dat Tran88; Uyeki, Timothy M.89; Van Zwol, Annelies90; Vaudry, Wendy91; Vidmar, Tjasa92; Yokota, Renata T. C.93; Zarogoulidis, Paul94; Nguyen-Van-Tam, Jonathan S.1; PRIDE Consortium Investigators
刊名LANCET RESPIRATORY MEDICINE
2014-05-01
DOI10.1016/S2213-2600(14)70041-4
2期:5页:395-404
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]STEM-CELL TRANSPLANTATION ; PANDEMIC INFLUENZA ; ANTIVIRAL TREATMENT ; RISK-FACTORS ; OSELTAMIVIR ; CHILDREN ; OUTCOMES ; THERAPY ; IMPACT ; ADULTS
英文摘要

Background Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.

Methods We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.

Findings We included data for 29 234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0.81; 95% CI 0.70-0.93; p=0.0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0.48; 95% CI 0.41-0.56; p<0.0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0.50; 95% CI 0.37-0.67; p<0.0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day′s delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1.23] [95% CI 1.18-1.28]; p<0.0001 for the increasing HR with each day′s delay).

Interpretation We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection.

语种英语
WOS记录号WOS:000336716300022
资助机构F Hoffmann-La Roche
引用统计
被引频次:237[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60889
专题北京大学第二临床医学院
作者单位1.Inst Nacl Enfermedades Resp, Epidemiol Res Unit, Mexico City, DF, Mexico
2.Catholic Childrens Hosp Wilhelmstift, Hamburg, Germany
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Dhaka Med Coll Hosp, Dhaka, Bangladesh
5.Minist Hlth Egypt, Cairo, Egypt
6.Gold Coast Hosp, Gold Coast, Australia
7.Natl Ctr Global Hlth & Med, Tokyo, Japan
8.Natl Inst Resp Dis Dr Emilio Coni, Santa Fe, Argentina
9.Tygerberg Hosp, Cape Town, South Africa
10.Shiraz Univ Med Sci, Ctr Hlth Policy Res, Shiraz, Iran
11.Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore
12.Helsinki Univ Hosp, Helsinki, Finland
13.King Hussein Canc Ctr, Dept Pediat, Amman, Jordan
14.Minist Def, Inst Med Prevent Def, Madrid, Spain
15.Minist Hlth, Riyadh, Saudi Arabia
16.Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia
17.Mil Med Acad, Clin Infect & Trop Dis, Belgrade 11002, Serbia
18.Haukeland Hosp, Dept Res & Dev, N-5021 Bergen, Norway
19.Univ Bergen, Dept Clin Sci, Influenza Ctr, Bergen, Norway
20.Hosp San Martin de Parana, Dept Infect Control, Entre Rios, Argentina
21.Univ Nottingham, Div Epidemiol & Publ Hlth, Nottingham NG5 1PB, England
22.King Saud Med City, Dept Med, Riyadh, Saudi Arabia
23.Res Bangladesh, Int Ctr Diarrhoeal Dis, Dhaka, Bangladesh
24.Govt Med Coll Bhavnagar, Dept Pharmacol, Bhavnagar, Gujarat, India
25.Sir Takhtsinhji Gen Hosp, Bhavnagar, Gujarat, India
26.Ctr Dis Control & Prevent, Atlanta, GA USA
27.Minist Salud Prov Buenos Aires, Buenos Aires, DF, Argentina
28.Santa Maria Misericordia Hosp, Udine, Italy
29.Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia
30.Kantonsspital St Gallen, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland
31.Inst Veille Sanit, St Maurice, France
32.Univ Sydney, Childrens Hosp Westmead, Natl Ctr Immunisat Res & Surveillance, Sydney, NSW 2006, Australia
33.Inst Mexicano Seguro Social, Mexico City, DF, Mexico
34.Med Univ Vienna, Vienna, Austria
35.Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China
36.Univ Barcelona, Bellvitge Inst Biomed Res, Hosp Univ Bellvitge, Dept Infect Dis, Barcelona, Spain
37.Univ Estadual Oeste Parana, Cascavel, Brazil
38.Univ Manitoba, Sect Pediat Infect Dis, Winnipeg, MB, Canada
39.Peter Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Parkville, Vic, Australia
40.Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic, Australia
41.Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Pediat Infect Dis, Aurora, CO USA
42.Chaim Sheba Med Ctr, Edmond & Lily Safra Childrens Hosp, Ramat Gan, Israel
43.CEMIC Univ Hosp, Clin Virol Lab, Buenos Aires, DF, Argentina
44.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China
45.Grp Hosp Sud Reunion, Ctr Hosp Univ, Paediat Intens Care Unit, Neonatal Intens Care Unit, St Pierre, Reunion
46.Univ La Reunion, Ctr Hosp Univ, Natl Inst Hlth & Med Res, Ctr Clin Invest 1410, St Pierre, Reunion
47.Univ La Reunion, Ctr Hosp Univ, Natl Inst Hlth & Med Res,Res & Dev Inst, Cyclotron Reunion Ocean Indien,Unite Mixte Rech P, St Denis, Reunion
48.Hosp Gen Univ Gregorio Maranon, Dept Clin Microbiol & Infect Dis, Madrid, Spain
49.Statens Serum Inst, Dept Infect Dis Epidemiol, Sect Natl Hlth Documentat & Res, DK-2300 Copenhagen, Denmark
50.Univ London Imperial Coll Sci Technol & Med, Div Infect Dis, Paediat Sect, London, England
51.Univ Fed Ciencias Saude Porto Alegre, Dept Obstet & Ginecol, Preceptora Residencia Med Hosp Femina, Porto Alegre, RS, Brazil
52.Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran
53.Univ Oxford, Nuffield Dept Populat Hlth, Natl Perinatal Epidemiol Unit, Oxford, England
54.Univ Zagreb, Sch Med, Univ Hosp Infect Dis, Zagreb 41001, Croatia
55.Pamela Youde Nethersole Eastern Hosp, Dept Intens Care, Hong Kong, Hong Kong, Peoples R China
56.Univ Mohammed V Souissi, Fac Med & Pharm, Mohammed V Mil Teaching Hosp, Biosafety Level & Res Lab 3, Rabat, Morocco
57.Univ Stellenbosch, Dept Obstet & Gynaecol, Cape Town, South Africa
58.China Med Univ, Affiliated Hosp 1, Dept Infect Dis, Shenyang, Peoples R China
59.Univ Toronto, Toronto Invas Bacterial Dis Network, Toronto, ON, Canada
60.Erciyes Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey
61.Lithuanian Univ Hlth Sci, Kaunas, Lithuania
62.Haukeland Hosp, Dept Med, Infect Dis Sect, N-5021 Bergen, Norway
63.Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Div Ocular Immunol, Baltimore, MD 21205 USA
64.Shahid Beheshti Univ Med Sci, Massih Daneshvari Hosp, Natl Res Inst TB & Lung Dis, Tehran, Iran
65.Minist Hlth, Natl Ctr Communicable Dis, Natl Influenza Ctr, Ulaanbaatar, Mongol Peo Rep
66.Dr Sami Ulus Res & Training Hosp Womens & Childre, Clin Pediat Neurol, Ankara, Turkey
67.Univ Birmingham, Sch Clin & Expt Med, Crit Care & Pain Perioperat Crit Care & Trauma Tr, Birmingham B15 2TT, W Midlands, England
68.Rambam Hlth Care Campus, Div Infect Dis, Haifa, Israel
69.Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Ctr, Nashville, TN USA
70.Fdn INFANT, Buenos Aires, DF, Argentina
71.Charite Univ Med Ctr, Dept Pediat, Div Pneumonol Immunol, Berlin, Germany
72.Univ Rovira & Virgili, Hosp Joan 23, Crit Care Dept, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Spain
73.Minist Salud Tucuman, San Miguel De Tucuman, Argentina
74.Bristol Childrens Hosp, Paediat Intens Care Unit, Bristol, Avon, England
75.Univ Bristol, Sch Clin Sci, Bristol Childrens Vaccine Ctr, Bristol, Avon, England
76.Yuzuncu Yil Univ, Fac Med, Dept Pulm Med, Van, Turkey
77.Fiocruz MS, Inst Oswaldo Cruz, Lab Resp Viruses, BR-21045900 Rio De Janeiro, Brazil
78.Uniwersytet Rzeszowski, Rzeszow, Poland
79.Univ Basel Hosp, Dept Emergency Med, CH-4031 Basel, Switzerland
80.Med Univ Warsaw, Dept Childrens Infect Dis, Warsaw, Poland
81.Istanbul Fac Med, Dept Pediat Infect Dis, Istanbul, Turkey
82.Gen Hosp Slovenj Gradec, Slovenj Gradec, Slovenia
83.Natl Univ Singapore Hosp, Div Microbiol, Mol Diagnost Ctr, Dept Lab Med, Singapore 117548, Singapore
84.Univ Alberta Hosp, Alberta Prov Lab Publ Hlth, Edmonton, AB T6G 2B7, Canada
85.Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB, Canada
86.Univ Hong Kong, Queen Mary Hosp, Carol Yu Ctr Infect, Hong Kong, Hong Kong, Peoples R China
87.Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Div Infect Dis, Hong Kong, Hong Kong, Peoples R China
88.Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
89.Univ Toronto, Hosp Sick Children, Dept Paediat, Div Infect Dis, Toronto, ON M5G 1X8, Canada
90.Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA
91.Vrije Univ Amsterdam Med Ctr, Dept Pediat Intens Care, Amsterdam, Netherlands
92.Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Div Infect Dis, Edmonton, AB, Canada
93.Minist Saude, Secretaria Vigilancia Saude, Dept Vigilancia Epidemiol, Brasilia, DF, Brazil
94.Democritus Univ Thrace, Univ Gen Hosp Alexandroupolis, Infect Dis Unit, Dragana, Greece
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GB/T 7714
Muthuri, Stella G.,Venkatesan, Sudhir,Myles, Puja R.,et al. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data[J]. LANCET RESPIRATORY MEDICINE,2014,2(5):395-404.
APA Muthuri, Stella G..,Venkatesan, Sudhir.,Myles, Puja R..,Leonardi-Bee, Jo.,Al Khuwaitir, Tarig S. A..,...&PRIDE Consortium Investigators.(2014).Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.LANCET RESPIRATORY MEDICINE,2(5),395-404.
MLA Muthuri, Stella G.,et al."Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data".LANCET RESPIRATORY MEDICINE 2.5(2014):395-404.
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