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学科主题: 临床医学
题名:
Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients
作者: Zhou, Ying1; Sheng, Xiao-yan1; Xu, Jun-yu1; Bi, Shan-shan2; Lu, Wei2; Cui, Yi-min1
关键词: cyclosporine ; population pharmacokinetics ; hematopoietic stem cell transplantation ; therapeutic drug monitoring
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
发表日期: 2013-07-01
DOI: 10.5414/CP201615
卷: 51, 期:7, 页:568-575
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: MODELS
英文摘要:

Objectives: The aim of this study is to investigate the population pharmacokinetics (PopPK) of cyclosporine (CsA) in the Chinese hematopoietic stem cell transplantation (HSCT) recipients for promoting the individualization of CsA administration. Methods: A total of 887 retrospective drug monitoring data points were collected from 58 HSCT recipients. Whole blood samples were collected at predose (C-0) and 2 hours (C-2) post dose. The administration of CsA was intermittent intravenous infusion, continuous intravenous infusion and oral. Population modeling was performed using the NONMEM (nonlinear mixed-effect modeling) program. A one compartment pharmacokinetic model was used to fit the data. Results: Body surface area (BSA), administration route and postoperative days were identified as significant covariates for clearance (CL) according to the final model: CL = 31.0 x (BsA/1.59)(0.761) x (ROUT) x (POD), where ROUT was 1.91 if the administration route was intravenous infusion, otherwise it is equal to 1. The POD was 0.818, 0.753, 0.539, and 0.509 for post-transplant Days 0 - 10, 11 - 20, 21 - 30 and more than 30 days, respectively. Administration route was a significant covariate for volume (V) according to the final model: V = 192 x (ROUT), where ROUT was 4.10, 3.63 and 1 when the administration route was continuous intravenous infusion, intermittent intravenous infusion and oral. The other covariates were not identified as a significant effect on CsA pharmacokinetic parameters. Conclusion: Body surface area, administration route and postoperative days should be considered in individual pharmacotherapy of cyclosporine for HSCT patient to achieve the desired therapeutic target.

语种: 英语
WOS记录号: WOS:000322350000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60891
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pharm, Base Clin Trial, Beijing 100034, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Ying,Sheng, Xiao-yan,Xu, Jun-yu,et al. Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2013,51(7):568-575.
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