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Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients
Zhou, Ying1; Sheng, Xiao-yan1; Xu, Jun-yu1; Bi, Shan-shan2; Lu, Wei2; Cui, Yi-min1
关键词cyclosporine population pharmacokinetics hematopoietic stem cell transplantation therapeutic drug monitoring
刊名INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
2013-07-01
DOI10.5414/CP201615
51期:7页:568-575
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]MODELS
英文摘要

Objectives: The aim of this study is to investigate the population pharmacokinetics (PopPK) of cyclosporine (CsA) in the Chinese hematopoietic stem cell transplantation (HSCT) recipients for promoting the individualization of CsA administration. Methods: A total of 887 retrospective drug monitoring data points were collected from 58 HSCT recipients. Whole blood samples were collected at predose (C-0) and 2 hours (C-2) post dose. The administration of CsA was intermittent intravenous infusion, continuous intravenous infusion and oral. Population modeling was performed using the NONMEM (nonlinear mixed-effect modeling) program. A one compartment pharmacokinetic model was used to fit the data. Results: Body surface area (BSA), administration route and postoperative days were identified as significant covariates for clearance (CL) according to the final model: CL = 31.0 x (BsA/1.59)(0.761) x (ROUT) x (POD), where ROUT was 1.91 if the administration route was intravenous infusion, otherwise it is equal to 1. The POD was 0.818, 0.753, 0.539, and 0.509 for post-transplant Days 0 - 10, 11 - 20, 21 - 30 and more than 30 days, respectively. Administration route was a significant covariate for volume (V) according to the final model: V = 192 x (ROUT), where ROUT was 4.10, 3.63 and 1 when the administration route was continuous intravenous infusion, intermittent intravenous infusion and oral. The other covariates were not identified as a significant effect on CsA pharmacokinetic parameters. Conclusion: Body surface area, administration route and postoperative days should be considered in individual pharmacotherapy of cyclosporine for HSCT patient to achieve the desired therapeutic target.

语种英语
WOS记录号WOS:000322350000004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60891
专题北京大学第一临床医学院_药剂科
北京大学药学院_药剂学系
作者单位1.Peking Univ, Hosp 1, Dept Pharm, Base Clin Trial, Beijing 100034, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Ying,Sheng, Xiao-yan,Xu, Jun-yu,et al. Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2013,51(7):568-575.
APA Zhou, Ying,Sheng, Xiao-yan,Xu, Jun-yu,Bi, Shan-shan,Lu, Wei,&Cui, Yi-min.(2013).Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients.INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,51(7),568-575.
MLA Zhou, Ying,et al."Population pharmacokinetic study of cyclosporine in hematopoietic stem cell transplant recipients".INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 51.7(2013):568-575.
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