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学科主题: 药学
题名:
Caged nucleotides/nucleosides and their photochemical biology
作者: Tang, Xinjing; Zhang, Jinhao; Sun, Jingjing; Wang, Yuan; Wu, Junzhou; Zhang, Lihe
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2013-12-07
DOI: 10.1039/c3ob41735b
卷: 11, 期:45, 页:7814-7824
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDE ; PHOTOREMOVABLE PROTECTING GROUPS ; REVERSIBLE TERMINATORS ; MAMMALIAN-CELLS ; CYCLIC-AMP ; DNA ; LIGHT ; DESIGN ; ADENOSINE ; CHEMISTRY
英文摘要:

Nucleotides and nucleosides are not only key units of DNA/RNA that store genetic information, but are also the regulators of many biological events of our lives. By caging the key functional groups or key residues of nucleotides with photosensitive moieties, it will be possible to trigger biological events of target nucleotides with spatiotemporal resolution and amplitude upon light activation or photomodulate polymerase reactions with the caged nucleotide analogues for next-generation sequencing (NGS) and bioorthogonal labeling. This review highlights three different caging strategies for nucleotides and demonstrates the photochemical biology of these caged nucleotides.

语种: 英语
所属项目编号: 2012CB720600 ; 21072015 ; NCET-10-0203
项目资助者: National Basic Research Program of China ("973" Program) ; National Science Foundation of China ; Program for New Century Excellent Talents in University ; Chinese Ministry of Education
WOS记录号: WOS:000327053100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60892
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Tang, Xinjing,Zhang, Jinhao,Sun, Jingjing,et al. Caged nucleotides/nucleosides and their photochemical biology[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2013,11(45):7814-7824.
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