IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3 beta in hepatocellular carcinoma
Zhu, Pengfei1,2; Lv, Jun3; Yang, Ziwei1,2; Guo, Limei4; Zhang, Ling5; Li, Meng1,2; Han, Wenling6; Chen, Xiangmei1,2; Zhuang, Hui1,2; Lu, Fengmin1,2
关键词Hepatocellular carcinoma Protocadherin 9 Tumor suppressor gene EMT GSK-3 beta
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-09-26
DOI10.1016/j.bbrc.2014.08.101
452期:3页:567-574
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Natural Science Foundation of China ; Research Fund from Ministry of Education of China ; National Natural Science Foundation of China ; Research Fund from Ministry of Education of China
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CANDIDATE TUMOR-SUPPRESSOR ; CHROMOSOME 13Q ; ANALYSIS REVEALS ; GENE-EXPRESSION ; CANCER ; SNAIL ; METHYLATION ; DIVERSITY ; MECHANISM ; COMPLEX
英文摘要

Protocadherin 9 (PCDH9) was found frequently lost in hepatocellular carcinoma (HCC). Here we investigated the role of PCDH9 in the development of HCC. We confirmed that PCDH9 was down-regulated in HCC tissues and cell lines compared with the adjacent non-tumor tissues. PCDH9 downregulation was significantly associated with malignant portal vein invasion of HCC patients. Gain- and loss-of-function studies revealed that downregulation of PCDH9 facilitated tumor cell migration and epithelial mesenchymal transition (EMT). We identified PCDH9 as a novel regulator of EMT by increasing the activity of GSK-3 beta and inhibiting Snail1, indicating its potential therapeutic value for reducing metastasis of HCC. (C) 2014 The Authors. Published by Elsevier Inc.

语种英语
所属项目编号81372603 ; 81101539 ; 20110001120017 ; B07001
资助者National Natural Science Foundation of China ; Research Fund from Ministry of Education of China ; National Natural Science Foundation of China ; Research Fund from Ministry of Education of China
WOS记录号WOS:000343023900043
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60897
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Guangdong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Henan Canc Hosp, Dept Hepatobiliary Surg, Zhengzhou, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci,Ctr Human Dis Genom, Key Lab Med Immunol,Minist Hlth,Dept Immunol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Pengfei,Lv, Jun,Yang, Ziwei,et al. Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3 beta in hepatocellular carcinoma[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,452(3):567-574.
APA Zhu, Pengfei.,Lv, Jun.,Yang, Ziwei.,Guo, Limei.,Zhang, Ling.,...&Lu, Fengmin.(2014).Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3 beta in hepatocellular carcinoma.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,452(3),567-574.
MLA Zhu, Pengfei,et al."Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3 beta in hepatocellular carcinoma".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452.3(2014):567-574.
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