学科主题基础医学
Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population
Wu, Qi1,2,3; Yu, Bo1,3,4; Chen, Yuewen5; Shao, Yong1,3,4; Zhang, Jie3,4; Zhong, Qili3,4; Peng, Xi3,4; Yang, Hong1,3; Hu, Xiaoping3,4; Chen, Bancheng3,4; Guan, Ming6; Wan, Jun1,3,7; Zhang, Wei5,7
关键词High-resolution melting analysis (HRMA) MAMDC1 Single-nucleotide polymorphisms (SNPs) Systemic lupus erythematosus (SLE)
刊名CLINICAL RHEUMATOLOGY
2011-10-01
DOI10.1007/s10067-011-1794-2
30期:10页:1373-1378
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]GENOME-WIDE ASSOCIATION ; VARIANTS ; GENE ; IDENTIFICATION ; ITGAM ; LOCI ; SLE
英文摘要

Systemic lupus erythematosus (SLE) is a complex immune disease affected by both genetic dispositions and environmental factors. Recently, the polymorphisms in MAMDC1 gene have been reported to associate with disease risk of SLE in European population. However, whether this association is replicated in Chinese population is unknown yet. A total of 491 SLE patients and 533 controls were recruited. Unlabeled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabeled probe successfully distinguished all genotypes. SNP rs961616 was associated with rash [P=0.015, odds ratio (OR)=0.73, 95% confidence interval (CI)=0.57-0.94] and photosensitivity (P=0.001, OR=0.63, 95% CI=0.48-0.84), but not the disease risk (P=0.133, OR=0.88, 95% CI=0.74-1.04), of SLE in Chinese population. Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.

语种英语
WOS记录号WOS:000297200400016
资助机构Shenzhen Science and Technology Project
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60900
专题北京大学基础医学院_生物化学与分子生物学系
北京大学临床肿瘤学院_内镜中心
北京大学临床肿瘤学院_护理部
作者单位1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Dept Biochem, Peking Univ Hlth Sci Ctr, Beijing, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
6.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou 510632, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Wu, Qi,Yu, Bo,Chen, Yuewen,et al. Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population[J]. CLINICAL RHEUMATOLOGY,2011,30(10):1373-1378.
APA Wu, Qi.,Yu, Bo.,Chen, Yuewen.,Shao, Yong.,Zhang, Jie.,...&Zhang, Wei.(2011).Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population.CLINICAL RHEUMATOLOGY,30(10),1373-1378.
MLA Wu, Qi,et al."Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population".CLINICAL RHEUMATOLOGY 30.10(2011):1373-1378.
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