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学科主题: 基础医学
题名:
Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population
作者: Wu, Qi1,2,3; Yu, Bo1,3,4; Chen, Yuewen5; Shao, Yong1,3,4; Zhang, Jie3,4; Zhong, Qili3,4; Peng, Xi3,4; Yang, Hong1,3; Hu, Xiaoping3,4; Chen, Bancheng3,4; Guan, Ming6; Wan, Jun1,3,7; Zhang, Wei5,7
关键词: High-resolution melting analysis (HRMA) ; MAMDC1 ; Single-nucleotide polymorphisms (SNPs) ; Systemic lupus erythematosus (SLE)
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2011-10-01
DOI: 10.1007/s10067-011-1794-2
卷: 30, 期:10, 页:1373-1378
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; VARIANTS ; GENE ; IDENTIFICATION ; ITGAM ; LOCI ; SLE
英文摘要:

Systemic lupus erythematosus (SLE) is a complex immune disease affected by both genetic dispositions and environmental factors. Recently, the polymorphisms in MAMDC1 gene have been reported to associate with disease risk of SLE in European population. However, whether this association is replicated in Chinese population is unknown yet. A total of 491 SLE patients and 533 controls were recruited. Unlabeled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabeled probe successfully distinguished all genotypes. SNP rs961616 was associated with rash [P=0.015, odds ratio (OR)=0.73, 95% confidence interval (CI)=0.57-0.94] and photosensitivity (P=0.001, OR=0.63, 95% CI=0.48-0.84), but not the disease risk (P=0.133, OR=0.88, 95% CI=0.74-1.04), of SLE in Chinese population. Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.

语种: 英语
项目资助者: Shenzhen Science and Technology Project
WOS记录号: WOS:000297200400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60900
Appears in Collections:基础医学院_生物化学与分子生物学系_期刊论文

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作者单位: 1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Dept Biochem, Peking Univ Hlth Sci Ctr, Beijing, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
6.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou 510632, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wu, Qi,Yu, Bo,Chen, Yuewen,et al. Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population[J]. CLINICAL RHEUMATOLOGY,2011,30(10):1373-1378.
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