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学科主题口腔医学
Abnormal Differentiation of Dental Pulp Cells in Cleidocranial Dysplasia
Yan, W. J.1,2; Zhang, C. Y.1; Yang, X.3; Liu, Z. N.4; Wang, X. Z.1; Sun, X. Y.1; Wang, Y. X.5; Zheng, S. G.1
关键词cell biology craniofacial anomalies bone remodeling regeneration craniofacial biology genetics osteogenesis osteoclasts
刊名JOURNAL OF DENTAL RESEARCH
2015-04-01
DOI10.1177/0022034514566655
94期:4页:577-583
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]PERIODONTAL-LIGAMENT CELLS ; ALTERED GENE-EXPRESSION ; OSTEOBLAST DIFFERENTIATION ; OSTEOCLAST FORMATION ; TOOTH DEVELOPMENT ; DECIDUOUS TEETH ; RUNX2 GENE ; CBFA1 ; BONE ; RESORPTION
英文摘要

Cleidocranial dysplasia (CCD) is a skeletal dysplasia caused by heterozygous mutations of RUNX2, a gene that is essential for the mineralization of bone and tooth. We isolated primary dental pulp cells from a 10-y-old patient and tested their proliferative capacity, alkaline phosphatase activity, and ability to form mineralized nodules, in comparison with those from 7 healthy children. All these measures were reduced in primary dental pulp cells from the CCD patient. The expression of the osteoblast/odontoblast-associated genes RUNX2, ALP, OCN, and DSPP was also found to be significantly decreased in the primary dental pulp cells of the CCD patient. The osteoclast-related markers TRAP, CTSK, CTR, and MMP9 were decreased in primary dental pulp cells cocultured with human peripheral blood mononuclear cells. Moreover, the expression of RANKL and the ratio of RANKL/OPG were both reduced in the cells from the CCD patient, indicating that the RUNX2 mutation interfered with the bone-remodeling pathway and decreased the capacity of primary dental pulp cells to support osteoclast differentiation. These effects may be partly responsible for the defects in tooth development and the retention of primary teeth that is typical of CCD.

语种英语
WOS记录号WOS:000351636500010
项目编号81070815
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60907
专题北京大学口腔医学院_口腔预防保健科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Div 1, Beijing 100081, Peoples R China
3.Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Stomatol, Beijing, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Yan, W. J.,Zhang, C. Y.,Yang, X.,et al. Abnormal Differentiation of Dental Pulp Cells in Cleidocranial Dysplasia[J]. JOURNAL OF DENTAL RESEARCH,2015,94(4):577-583.
APA Yan, W. J..,Zhang, C. Y..,Yang, X..,Liu, Z. N..,Wang, X. Z..,...&Zheng, S. G..(2015).Abnormal Differentiation of Dental Pulp Cells in Cleidocranial Dysplasia.JOURNAL OF DENTAL RESEARCH,94(4),577-583.
MLA Yan, W. J.,et al."Abnormal Differentiation of Dental Pulp Cells in Cleidocranial Dysplasia".JOURNAL OF DENTAL RESEARCH 94.4(2015):577-583.
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