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学科主题口腔医学
Cell response of nanographene platelets to human osteoblast-like MG63 cells
Zhang, X.1; Li, M.1; Wang, Y. B.1,2; Cheng, Y.1; Zheng, Y. F.1,3; Xi, T. F.1; Wei, S. C.1,4
关键词nanographene platelets cytotoxicity MG63 cells LDH ALP
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2014-03-01
DOI10.1002/jbm.a.34751
102期:3页:732-742
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program (973) of China
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]GRAPHENE OXIDE ; CARBON NANOTUBES ; NANOCOMPOSITES ; DELIVERY
英文摘要

The biologic/cytotoxic effects of dispersed nanographene platelets (NGPs) on human osteosarcoma cells (MG63 cell line) were first studied by examining cell viability, cycle, apoptosis, change in morphology, lactate dehydrogenase (LDH) release, alkaline phosphatase (ALP) activity, and inflammation. The results shown that the cell cytotoxicity of the dispersed NGPs exhibited dose-dependent characters, which had no obvious cytotoxic effects to MG63 cells at the concentration less than 10g mL(-1), whereas could postpone cell cycle, promote cell apoptosis, damage cell microstructure, induce serious tumor necrosis factor- expression and greatly reduce ALP activity of MG63 cells at higher concentration of NGPs (>10 mu g mL(-1)). Besides, NGPs had little influence on the LDH leakage. The cytotoxic mechanism of NGPs to MG63 cells was speculated to be intracellular activity with no physical damage of plasma membrane. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 732-742, 2014.

语种英语
所属项目编号31070846 ; 30870623 ; 2011AA030103 ; 2009CB930004 ; 2012CB619102
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program (973) of China ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program (973) of China
WOS记录号WOS:000329679100013
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60908
专题北京大学口腔医学院
作者单位1.Angstron Mat LLC, Dayton, OH 45404 USA
2.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhang, X.,Li, M.,Wang, Y. B.,et al. Cell response of nanographene platelets to human osteoblast-like MG63 cells[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(3):732-742.
APA Zhang, X..,Li, M..,Wang, Y. B..,Cheng, Y..,Zheng, Y. F..,...&Wei, S. C..(2014).Cell response of nanographene platelets to human osteoblast-like MG63 cells.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,102(3),732-742.
MLA Zhang, X.,et al."Cell response of nanographene platelets to human osteoblast-like MG63 cells".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102.3(2014):732-742.
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