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学科主题: 口腔医学
题名:
Cell response of nanographene platelets to human osteoblast-like MG63 cells
作者: Zhang, X.1; Li, M.1; Wang, Y. B.1,2; Cheng, Y.1; Zheng, Y. F.1,3; Xi, T. F.1; Wei, S. C.1,4
关键词: nanographene platelets ; cytotoxicity ; MG63 cells ; LDH ; ALP
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2014-03-01
DOI: 10.1002/jbm.a.34751
卷: 102, 期:3, 页:732-742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: GRAPHENE OXIDE ; CARBON NANOTUBES ; NANOCOMPOSITES ; DELIVERY
英文摘要:

The biologic/cytotoxic effects of dispersed nanographene platelets (NGPs) on human osteosarcoma cells (MG63 cell line) were first studied by examining cell viability, cycle, apoptosis, change in morphology, lactate dehydrogenase (LDH) release, alkaline phosphatase (ALP) activity, and inflammation. The results shown that the cell cytotoxicity of the dispersed NGPs exhibited dose-dependent characters, which had no obvious cytotoxic effects to MG63 cells at the concentration less than 10g mL(-1), whereas could postpone cell cycle, promote cell apoptosis, damage cell microstructure, induce serious tumor necrosis factor- expression and greatly reduce ALP activity of MG63 cells at higher concentration of NGPs (>10 mu g mL(-1)). Besides, NGPs had little influence on the LDH leakage. The cytotoxic mechanism of NGPs to MG63 cells was speculated to be intracellular activity with no physical damage of plasma membrane. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 732-742, 2014.

语种: 英语
所属项目编号: 31070846 ; 30870623 ; 2011AA030103 ; 2009CB930004 ; 2012CB619102
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program (973) of China
WOS记录号: WOS:000329679100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60908
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Angstron Mat LLC, Dayton, OH 45404 USA
2.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Zhang, X.,Li, M.,Wang, Y. B.,et al. Cell response of nanographene platelets to human osteoblast-like MG63 cells[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(3):732-742.
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