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学科主题基础医学
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice
Xian, Xunde2,3,6; Ding, Yu1; Zhang, Ling2,3; Wang, Yanan2,3; McNutt, Michael A.4; Ross, Colin5; Hayden, Michael R.5; Deng, Xuming1; Liu, George2,3
关键词Lipoprotein lipase (LPL) Hypertriglyceridemia Lipoproteins Carotid artery Thrombosis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-08-07
DOI10.1016/j.bbrc.2009.05.101
385期:4页:563-569
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ACTIVATOR INHIBITOR TYPE-1 ; LIPOPROTEIN-LIPASE GENE ; FOAM CELL-FORMATION ; DEFICIENT MICE ; SEVERE HYPERTRIGLYCERIDEMIA ; VENOUS THROMBOEMBOLISM ; THROMBUS FORMATION ; METABOLIC SYNDROME ; LIPID DEPOSITION ; KNOCKOUT MICE
英文摘要

Enhanced Susceptibility to atherosclerosis from severe hypertriglyceridemia (HTG) resulting from lipoprotein lipase (LPL) deficiency has been demonstrated in Our recent findings which employed a unique mouse model. In the present Study we provide further evidence that severe HTG due to LPL deficiency also promotes an atherothrombotic response to arterial injury induced by ferric chloride in a severe combined hyperlipidemic mouse model. Methods and results: A Mouse model (LPL-/ XApoE(-/-) double knockout, DKO) with severe combined hyperlipidemia was established by crossing ApoE and LPL-deficient mice. The common carotid arteries of ApoE knockout (EKO) and DKO mice were Subjected to injury by ferric chloride, and the formation of arterial thrombosis together with various markers were compared in these lesions. DKO mice demonstrated significantly enhanced thrombus formation overlying atherosclerotic plaque after injury, which contained smooth muscle cells, macrophages, and neutral lipid. The area of neointima, mean intima/media ratios, and the percentage Of luminal stenosis were significantly greater (P < 0.01) in DKO mice. Compared with EKO mice, the expression of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1) were increased in DKO mice. Conclusions: Severe combined hyperlipidemia promotes thrombosis after ferric chloride injury to atherosclerotic vessels and HTG plays a major role in the process. (c) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000267396500015
项目编号30470695
资助机构National Natural Science Foundation of the People&prime ; s Republic of China ; Program for Changjiang Scholars Innovative Research Team in University (PCSIRT)
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60916
专题北京大学基础医学院_心血管所
北京大学第三临床医学院_呼吸科
作者单位1.Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130062, Jilin, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC, Canada
6.Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA
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GB/T 7714
Xian, Xunde,Ding, Yu,Zhang, Ling,et al. Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,385(4):563-569.
APA Xian, Xunde.,Ding, Yu.,Zhang, Ling.,Wang, Yanan.,McNutt, Michael A..,...&Liu, George.(2009).Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,385(4),563-569.
MLA Xian, Xunde,et al."Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 385.4(2009):563-569.
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