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学科主题: 临床医学
题名:
Investigation of EGFR copy-number variations in skin cancers
作者: Zhang, Jie1,2,3; Zhang, Richu4; Shao, Yong1,2,3; Chen, Bancheng1,2,3; Hu, Xiaoping1,2,3; Wan, Jun1,3,5; Zhang, Chao1,3; Zhang, Wei1,5,6; Yu, Bo1,2,3
关键词: EGFR ; copy-number variations (CNVs) ; basal cell carcinoma (BCC) ; squamous cell carcinoma (SCC) ; actinic keratosis (AK)
刊名: EUROPEAN JOURNAL OF ONCOLOGY
发表日期: 2011
卷: 16, 期:1, 页:15-19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; SQUAMOUS-CELL CARCINOMAS ; LUNG-CANCER ; GEFITINIB SENSITIVITY ; GENE AMPLIFICATION ; PROTEIN EXPRESSION ; HUMAN GENOME ; PHASE-II ; HEAD ; NECK
英文摘要:

Aim. The epidermal growth factor receptor (EGFR) family members play a considerable role in carcinogenesis. Copy number variations (CNVs) have been discovered to have phenotypic consequences and to be associated with various types of cancer. CNVs of EGFR were associated with cancer pathogenesis in recent studies. However, few studies were performed in skin cancer. In this study, we aim to examine the CNVs of EGFR in skin samples. Materials and methods. A total of 195 paired-samples including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and actinic keratosis (AK) were included. Real-time PCR was used for the quantification of EGFR copy numbers. Results. CNVs of EGFR showed statistical differences between cancer samples (both SCC and BCC) and normal tissues (p<0.05). Association analysis showed that the frequencies of EGFR′s CNVs were correlated with the severity of skin abnormalities (p=0.011). Conclusions. CNVs of EGFR are associated with SCC and BCC but not with AK. Eur. J. Oncol., 16 (1), 15-19, 2011

语种: 英语
所属项目编号: 200901013 ; 081ky24
项目资助者: Shenzhen Science and Technology Project ; Taizhou Science and Technology Bureau
WOS记录号: WOS:000292163800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60928
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 510632, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 510632, Guangdong, Peoples R China
4.Taizhou Municipal Hosp, Dept Gen Surg, Taizhou, Zhejiang, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
6.Jinan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Zhang, Jie,Zhang, Richu,Shao, Yong,et al. Investigation of EGFR copy-number variations in skin cancers[J]. EUROPEAN JOURNAL OF ONCOLOGY,2011,16(1):15-19.
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