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学科主题临床医学
Investigation of EGFR copy-number variations in skin cancers
Zhang, Jie1,2,3; Zhang, Richu4; Shao, Yong1,2,3; Chen, Bancheng1,2,3; Hu, Xiaoping1,2,3; Wan, Jun1,3,5; Zhang, Chao1,3; Zhang, Wei1,5,6; Yu, Bo1,2,3
关键词EGFR copy-number variations (CNVs) basal cell carcinoma (BCC) squamous cell carcinoma (SCC) actinic keratosis (AK)
刊名EUROPEAN JOURNAL OF ONCOLOGY
2011
16期:1页:15-19
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; SQUAMOUS-CELL CARCINOMAS ; LUNG-CANCER ; GEFITINIB SENSITIVITY ; GENE AMPLIFICATION ; PROTEIN EXPRESSION ; HUMAN GENOME ; PHASE-II ; HEAD ; NECK
英文摘要

Aim. The epidermal growth factor receptor (EGFR) family members play a considerable role in carcinogenesis. Copy number variations (CNVs) have been discovered to have phenotypic consequences and to be associated with various types of cancer. CNVs of EGFR were associated with cancer pathogenesis in recent studies. However, few studies were performed in skin cancer. In this study, we aim to examine the CNVs of EGFR in skin samples. Materials and methods. A total of 195 paired-samples including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and actinic keratosis (AK) were included. Real-time PCR was used for the quantification of EGFR copy numbers. Results. CNVs of EGFR showed statistical differences between cancer samples (both SCC and BCC) and normal tissues (p<0.05). Association analysis showed that the frequencies of EGFR′s CNVs were correlated with the severity of skin abnormalities (p=0.011). Conclusions. CNVs of EGFR are associated with SCC and BCC but not with AK. Eur. J. Oncol., 16 (1), 15-19, 2011

语种英语
WOS记录号WOS:000292163800003
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60928
专题北京大学深圳医院_皮肤性病科
作者单位1.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 510632, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 510632, Guangdong, Peoples R China
4.Taizhou Municipal Hosp, Dept Gen Surg, Taizhou, Zhejiang, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
6.Jinan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China
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GB/T 7714
Zhang, Jie,Zhang, Richu,Shao, Yong,et al. Investigation of EGFR copy-number variations in skin cancers[J]. EUROPEAN JOURNAL OF ONCOLOGY,2011,16(1):15-19.
APA Zhang, Jie.,Zhang, Richu.,Shao, Yong.,Chen, Bancheng.,Hu, Xiaoping.,...&Yu, Bo.(2011).Investigation of EGFR copy-number variations in skin cancers.EUROPEAN JOURNAL OF ONCOLOGY,16(1),15-19.
MLA Zhang, Jie,et al."Investigation of EGFR copy-number variations in skin cancers".EUROPEAN JOURNAL OF ONCOLOGY 16.1(2011):15-19.
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