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IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Kidney injury molecule-1
作者: Bonventre, Joseph V.1,2; Yang, Li2,3
关键词: acute kidney injury ; kidney injury molecule-1 ; urinary biomarker
刊名: CURRENT OPINION IN CRITICAL CARE
发表日期: 2010-12-01
DOI: 10.1097/MCC.0b013e32834008d3
卷: 16, 期:6, 页:556-561
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BIOMARKER QUALIFICATION ; URINARY BIOMARKERS ; EMERGING ROLE ; RENAL INJURY ; NEPHROTOXICITY ; TRANSPLANTATION ; EXPRESSION ; TOLERANCE ; TOXICITY ; PROTEIN
英文摘要:

Purpose of review

To review the new findings about the physiological roles of kidney injury molecule-1 (KIM-1) and the rapidly expanding evidence for this molecule as a promising biomarker in preclinical kidney toxicity evaluation and various human kidney diseases.

Recent findings

KIM-1 has attracted increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. There is rapidly accumulating evidence from both animal models and clinical studies that urinary KIM-1 is a sensitive and specific urinary biomarker for various forms of nephrotoxic injury, cardiac surgery-induced kidney injury, transplant rejection, and chronic kidney diseases.

Summary

KIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal epithelial cell into a phagocyte, with potentially important pathophysiological implications for modulation of the immune response and repair process after injury. KIM-1 serves as a highly sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic target for various kidney diseases.

语种: 英语
WOS记录号: WOS:000284140100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60929
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Brigham & Womens Hosp, Harvard Inst Med, Div Renal, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Dept Med, Boston, MA USA
3.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China

Recommended Citation:
Bonventre, Joseph V.,Yang, Li. Kidney injury molecule-1[J]. CURRENT OPINION IN CRITICAL CARE,2010,16(6):556-561.
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