IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Kidney injury molecule-1
Bonventre, Joseph V.1,2; Yang, Li2,3
关键词acute kidney injury kidney injury molecule-1 urinary biomarker
刊名CURRENT OPINION IN CRITICAL CARE
2010-12-01
DOI10.1097/MCC.0b013e32834008d3
16期:6页:556-561
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine
研究领域[WOS]General & Internal Medicine
关键词[WOS]BIOMARKER QUALIFICATION ; URINARY BIOMARKERS ; EMERGING ROLE ; RENAL INJURY ; NEPHROTOXICITY ; TRANSPLANTATION ; EXPRESSION ; TOLERANCE ; TOXICITY ; PROTEIN
英文摘要

Purpose of review

To review the new findings about the physiological roles of kidney injury molecule-1 (KIM-1) and the rapidly expanding evidence for this molecule as a promising biomarker in preclinical kidney toxicity evaluation and various human kidney diseases.

Recent findings

KIM-1 has attracted increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. There is rapidly accumulating evidence from both animal models and clinical studies that urinary KIM-1 is a sensitive and specific urinary biomarker for various forms of nephrotoxic injury, cardiac surgery-induced kidney injury, transplant rejection, and chronic kidney diseases.

Summary

KIM-1 mediates epithelial phagocytosis in the injured kidney converting the proximal epithelial cell into a phagocyte, with potentially important pathophysiological implications for modulation of the immune response and repair process after injury. KIM-1 serves as a highly sensitive and specific urinary biomarker for kidney injury and may also be a therapeutic target for various kidney diseases.

语种英语
WOS记录号WOS:000284140100007
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60929
专题北京大学第一临床医学院_肾脏内科
作者单位1.Brigham & Womens Hosp, Harvard Inst Med, Div Renal, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Dept Med, Boston, MA USA
3.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
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GB/T 7714
Bonventre, Joseph V.,Yang, Li. Kidney injury molecule-1[J]. CURRENT OPINION IN CRITICAL CARE,2010,16(6):556-561.
APA Bonventre, Joseph V.,&Yang, Li.(2010).Kidney injury molecule-1.CURRENT OPINION IN CRITICAL CARE,16(6),556-561.
MLA Bonventre, Joseph V.,et al."Kidney injury molecule-1".CURRENT OPINION IN CRITICAL CARE 16.6(2010):556-561.
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