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学科主题: 公共卫生
题名:
Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro
作者: Zhao, Jie1; Zhao, Jia-Xi1; Xu, Ya-Jun1,2
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/204187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: FETAL ALCOHOL SYNDROME ; DIETARY NUCLEOTIDES ; EXPOSURE ; BRAIN ; MOUSE ; SUPPLEMENTATION ; EMBRYOS ; ACID
英文摘要:

The objective of this study was to assess whether nucleotides supplementation in vitro could suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides supplementation (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) improved the growth parameters to some extent, and the protective effects peaked at 4.00 mg/L. In MB cell micromass culture system, exposure to 4.0 mg/mL ethanol for 5 days resulted in suppression of proliferation and differentiation. Supplementation of nucleotides (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) showed some protective effects, which peaked at 4.00 mg/L, too. The present research indicated that nucleotides supplementation might be of some benefit in the prevention of ethanol-induced birth defects; however, appropriate dosage requires attention.

语种: 英语
所属项目编号: 7092060
项目资助者: Natural Sciences Foundations of Beijing
WOS记录号: WOS:000327344600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60930
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Jie,Zhao, Jia-Xi,Xu, Ya-Jun. Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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