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Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro
Zhao, Jie1; Zhao, Jia-Xi1; Xu, Ya-Jun1,2
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/204187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]FETAL ALCOHOL SYNDROME ; DIETARY NUCLEOTIDES ; EXPOSURE ; BRAIN ; MOUSE ; SUPPLEMENTATION ; EMBRYOS ; ACID
英文摘要

The objective of this study was to assess whether nucleotides supplementation in vitro could suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides supplementation (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) improved the growth parameters to some extent, and the protective effects peaked at 4.00 mg/L. In MB cell micromass culture system, exposure to 4.0 mg/mL ethanol for 5 days resulted in suppression of proliferation and differentiation. Supplementation of nucleotides (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) showed some protective effects, which peaked at 4.00 mg/L, too. The present research indicated that nucleotides supplementation might be of some benefit in the prevention of ethanol-induced birth defects; however, appropriate dosage requires attention.

语种英语
WOS记录号WOS:000327344600001
项目编号7092060
资助机构Natural Sciences Foundations of Beijing
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60930
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Jie,Zhao, Jia-Xi,Xu, Ya-Jun. Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Zhao, Jie,Zhao, Jia-Xi,&Xu, Ya-Jun.(2013).Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro.BIOMED RESEARCH INTERNATIONAL.
MLA Zhao, Jie,et al."Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro".BIOMED RESEARCH INTERNATIONAL (2013).
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