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Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice
Shen, Ning1; Wang, Jing1; Zhao, Mingwu1; Pei, Fei2; He, Bei1
关键词Airway inflammation interleukin-17 antibody tobacco-smoke-exposed
刊名INHALATION TOXICOLOGY
2011-03-01
DOI10.3109/08958378.2011.559603
23期:4页:212-218
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]T-CELLS ; IL-17 ; CYTOKINE ; DISEASE ; INTERLEUKIN-17 ; EXPRESSION ; LIGAND ; MODEL ; COPD
英文摘要

Context: Our previous study showed that the interleukin-17 (IL-17) concentration in lung tissue and in bronchoalveolar lavage fluid (BALF) of rats with tobacco-smoke-induced chronic obstructive pulmonary disease (COPD) was higher than that of control group. However, whether IL-17 inhibitor could decrease the effect of tobacco smoking is not known yet.

Objectives: To investigate the significance of IL-17 antibodies (Ab) in tobacco-smoke-exposed (TSE) mice.

Materials and methods: Male C57/BL6 mice were randomly divided into three groups: TSE group, TSE + anti-IL-17 Ab group, and control group. The number of cells in BALF and the concentrations of IL-17, IL-6, IL-8 and MUC5AC in BALF and lung tissue homogenate were measured. Pulmonary function was measured by pressure sensors, and histologic analysis of the lungs was done in each group.

Results: Lung function tests in TSE + anti-IL-17 Ab group were the same compared with TSE group (P > 0.05). The total cell count and the number of neutrophil cells in BALF were significantly higher in TSE group than the normal control group (P < 0.01). Compared with the TSE group, the total cell count in TSE + anti-IL-17 Ab group was decreased, and the percentage of neutrophils in BALF was highly decreased (P < 0.01). Airway inflammation was alleviated in TSE + anti-IL-17 Ab group by histologic analysis. The concentrations of IL-17 in lung tissue were significantly lower in TSE + anti-IL-17 Ab group than in TSE group (P < 0.01). IL-17 was mainly expressed in the epithelial cells in the airways of TSE mice. The concentration of IL-6, IL-8 and MUC5AC in BALF was decreased in TSE + anti-IL-17 Ab group compared with TSE group.

Discussion and conclusions: These data support a potential role for IL-17 in airway neutrophilic inflammation in TSE mice. Anti-IL-17 decreased the number of neutrophils as well as the concentration of MUC5AC in the BALF and attenuated neutrophilic airway inflammation.

语种英语
WOS记录号WOS:000289163700005
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60941
专题北京大学第三临床医学院_呼吸科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Shen, Ning,Wang, Jing,Zhao, Mingwu,et al. Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice[J]. INHALATION TOXICOLOGY,2011,23(4):212-218.
APA Shen, Ning,Wang, Jing,Zhao, Mingwu,Pei, Fei,&He, Bei.(2011).Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice.INHALATION TOXICOLOGY,23(4),212-218.
MLA Shen, Ning,et al."Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice".INHALATION TOXICOLOGY 23.4(2011):212-218.
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