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Effect of L-arginine on pulmonary artery smooth muscle cell apoptosis in rats with hypoxic pulmonary vascular structural remodeling
Sumou, IK; Du, JB; Wei, B; Zhang, CY; Qi, JG; Tang, CS
关键词hypoxia pulmonary artery arginine apoptosis
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2006
DOI10.1111/j.1745-7270.2006.00131.x
38期:1页:15-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HYPERTENSION ; EXPRESSION
英文摘要

This study investigated the effect of L-arginine (L-Arg) on the apoptosis of pulmonary artery smooth muscle cells (PASMC) in rats with hypoxic pulmonary vascular structural remodeling, and its mechanisms. Seventeen Wistar rats were randomly divided into a control group (n= 5), a hypoxia group (n= 7), and a hypoxia+L-Arg group (n= 5). The morphologic changes of lung tissues were observed under optical microscope. Using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphatebiotin nick end labeling assay, the apoptosis of PASMC was examined. Fas expression in PASMC was examined using immunohistochemistry. The results showed that the percentage of muscularized artery in small pulmonary vessels, and the relative medial thickness and relative medial area of the small and median pulmonary muscularized arteries in the hypoxic group were all significantly increased. Pulmonary vascular structural remodeling developed after hypoxia. Apoptotic smooth muscle cells of the small and median pulmonary arteries in the hypoxia group were significantly less than those in the control group. After 14 d of hypoxia, Fas expression by smooth muscle cells of median and small pulmonary arteries was significantly inhibited. L-Arg significantly inhibited hypoxic pulmonary vascular structural remodeling in association with an augmentation of apoptosis of smooth muscle cells as well as Fas expression in PASMC. These results showed that L-Arg could play an important role in attenuating hypoxic pulmonary vascular structural remodeling by upregulating Fas expression in PASMC, thus promoting the apoptosis of PASMC.

语种英语
WOS记录号WOS:000234840400003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60942
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing 100034, Peoples R China
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Sumou, IK,Du, JB,Wei, B,et al. Effect of L-arginine on pulmonary artery smooth muscle cell apoptosis in rats with hypoxic pulmonary vascular structural remodeling[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2006,38(1):15-21.
APA Sumou, IK,Du, JB,Wei, B,Zhang, CY,Qi, JG,&Tang, CS.(2006).Effect of L-arginine on pulmonary artery smooth muscle cell apoptosis in rats with hypoxic pulmonary vascular structural remodeling.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,38(1),15-21.
MLA Sumou, IK,et al."Effect of L-arginine on pulmonary artery smooth muscle cell apoptosis in rats with hypoxic pulmonary vascular structural remodeling".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 38.1(2006):15-21.
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