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IR@PKUHSC  > 北京大学第二临床医学院  > 放射科  > 期刊论文
学科主题: 临床医学
题名:
Magnetosonoporation: Instant Magnetic Labeling of Stem Cells
作者: Qiu, Bensheng1; Xie, Daohai1,2; Walczak, Piotr3,8; Li, Xubin1,4; Ruiz-Cabello, Jesus5,6; Minoshima, Satoshi1; Bulte, Jeff W. M.3,7,8,9; Yang, Xiaoming1
关键词: MRI ; stem cells ; magnetosonoporation ; superparamagnetic iron oxide particles ; MR cell labeling
刊名: MAGNETIC RESONANCE IN MEDICINE
发表日期: 2010-06-01
DOI: 10.1002/mrm.22348
卷: 63, 期:6, 页:1437-1441
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: IN-VIVO TRACKING ; PROGENITOR CELLS ; CONTRAST AGENTS ; TRANSFECTION ; DELIVERY ; NANOPARTICLES ; FERUMOXIDES ; TUMORS ; MRI
英文摘要:

The purpose of this study was to develop an instant MR cell labeling technique, called magnetosonoporation. First, a magnetosonoporation apparatus was successfully established for MR labeling of stem cells. Then, the safety of this new cell labeling approach was confirmed by evaluation of cell viability, proliferation, and differentiation of magnetosonoporation-labeled and unlabeled C17.2 neural stem cells. Subsequently, the feasibility of using in vivo MRI to detect magnetosonoporation/Feridex-labeled stem cells was validated in living animals and confirmed by histologic correlation. The magnetosonoporation technique is expected to be convenient, efficient, and safe for future clinical application of MRI-guided cell therapies. Magn Reson Med 63:1437-1441, 2010. (C) 2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: R01 HL078672 ; RO1 NS045062 ; 0719
项目资助者: NIH ; RSNA RSD
WOS记录号: WOS:000278164400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60953
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.Univ Washington, Dept Radiol, Image Guided Biomol Intervent Sect, Sch Med, Seattle, WA 98195 USA
2.Suzhou Univ, Dept Radiol, Sch Med, Suzhou, Jiangsu, Peoples R China
3.Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol, Div MR Res, Baltimore, MD USA
4.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100871, Peoples R China
5.Univ Complutense Madrid, Inst Estudios Biofunc, E-28040 Madrid, Spain
6.Univ Complutense Madrid, CIBER Enfermedades Resp, E-28040 Madrid, Spain
7.Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD USA
8.Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD USA
9.Johns Hopkins Univ, Sch Med, Cellular Imaging Sect, Inst Cell Engn, Baltimore, MD USA

Recommended Citation:
Qiu, Bensheng,Xie, Daohai,Walczak, Piotr,et al. Magnetosonoporation: Instant Magnetic Labeling of Stem Cells[J]. MAGNETIC RESONANCE IN MEDICINE,2010,63(6):1437-1441.
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