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学科主题: 公共卫生
题名:
Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation
作者: Liu, Duojian1; Wu, Jing1; Ouyang, Li1,2; Wang, Jingyu1,2
刊名: PLOS ONE
发表日期: 2014-02-25
DOI: 10.1371/journal.pone.0089805
卷: 9, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: STABLE CARBON ; FRACTIONATION ; EXPOSURE ; DIET ; PB
英文摘要:

It has been reported in previous research that the lead isotopic composition of blood, urine and feces samples statistically differed from the given lead sources in Sprague-Dawley (SD) rats. However, the reason for this phenomenon is still unclear. An animal experiment was performed to investigate the lead isotope fractionation in diverse biological samples (i.e., lungs, liver, kidneys, bone) and to explore the possible reasons. SD rats were intratracheally instilled with lead acetate at the concentrations of 0, 0.02, 0.2, and 2 mg/kg body weight. Biological samples were collected for lead isotope analysis using an inductively coupled plasma mass spectrometry (ICP-MS). Significant differences are observed in lead isotope abundances among the diverse biological samples. The lead isotope abundances (Pb-206, Pb-207 and Pb-208) in diverse biological samples show different degrees and directions of departure from the given lead source. The results suggest that differences in enrichment or depletion capacity for each lead isotope in the various tissues might lead to the variation in lead isotopic abundances in tissues. Moreover, a nonlinear relationship between the blood lead level and the lead isotope abundances in liver and bone is observed. When the whole-blood level is higher than 50 ng/mL, the lead isotopic compositions of biological samples tend to be the same. Thus, the data support the speculation of a fractionation functional threshold.

语种: 英语
所属项目编号: 30972434
项目资助者: Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000332385900086
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60956
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Duojian,Wu, Jing,Ouyang, Li,et al. Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation[J]. PLOS ONE,2014,9(2).
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