IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation
Liu, Duojian1; Wu, Jing1; Ouyang, Li1,2; Wang, Jingyu1,2
刊名PLOS ONE
2014-02-25
DOI10.1371/journal.pone.0089805
9期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Natural Science Foundation of China (NSFC) ; Natural Science Foundation of China (NSFC)
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]STABLE CARBON ; FRACTIONATION ; EXPOSURE ; DIET ; PB
英文摘要

It has been reported in previous research that the lead isotopic composition of blood, urine and feces samples statistically differed from the given lead sources in Sprague-Dawley (SD) rats. However, the reason for this phenomenon is still unclear. An animal experiment was performed to investigate the lead isotope fractionation in diverse biological samples (i.e., lungs, liver, kidneys, bone) and to explore the possible reasons. SD rats were intratracheally instilled with lead acetate at the concentrations of 0, 0.02, 0.2, and 2 mg/kg body weight. Biological samples were collected for lead isotope analysis using an inductively coupled plasma mass spectrometry (ICP-MS). Significant differences are observed in lead isotope abundances among the diverse biological samples. The lead isotope abundances (Pb-206, Pb-207 and Pb-208) in diverse biological samples show different degrees and directions of departure from the given lead source. The results suggest that differences in enrichment or depletion capacity for each lead isotope in the various tissues might lead to the variation in lead isotopic abundances in tissues. Moreover, a nonlinear relationship between the blood lead level and the lead isotope abundances in liver and bone is observed. When the whole-blood level is higher than 50 ng/mL, the lead isotopic compositions of biological samples tend to be the same. Thus, the data support the speculation of a fractionation functional threshold.

语种英语
所属项目编号30972434
资助者Natural Science Foundation of China (NSFC) ; Natural Science Foundation of China (NSFC)
WOS记录号WOS:000332385900086
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60956
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Duojian,Wu, Jing,Ouyang, Li,et al. Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation[J]. PLOS ONE,2014,9(2).
APA Liu, Duojian,Wu, Jing,Ouyang, Li,&Wang, Jingyu.(2014).Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation.PLOS ONE,9(2).
MLA Liu, Duojian,et al."Variations in Lead Isotopic Abundances in Sprague-Dawley Rat Tissues: Possible Reason of Formation".PLOS ONE 9.2(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Duojian]的文章
[Wu, Jing]的文章
[Ouyang, Li]的文章
百度学术
百度学术中相似的文章
[Liu, Duojian]的文章
[Wu, Jing]的文章
[Ouyang, Li]的文章
必应学术
必应学术中相似的文章
[Liu, Duojian]的文章
[Wu, Jing]的文章
[Ouyang, Li]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。