北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 期刊论文
学科主题: 口腔医学
题名:
Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity
作者: Guo, CB; Cui, NB; Yu, GY; Liu, DX; Meng, SC; Song, Q
刊名: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2003-08-01
DOI: 10.1016/S0278-2391(03)00237-4
卷: 61, 期:8, 页:909-912
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: BREAST-CANCER ; SYNTHASE FAS ; PREDICTOR ; INHIBITION ; RECURRENCE ; DISEASE ; TARGET ; STAGE
英文摘要:

Purposes: Inhibition of cerulenin on the endogenous fatty acid synthetic activities of oral squamous cell carcinoma (OSCC) and normal oral mucosa was assayed.

Methods: Squamous cell carcinoma and normal oral mucosa were collected fresh from surgical specimens. The collected tissues were minced in RPMI 1640 and divided into 3 groups: cerulenin treated, dimethylsuffoxide treated, and control. The tissues were incubated in [1(2)-C-14]acetic acid, sodium salt for the last 2.5 hours of the treatment at 37degreesC in 5% CO2. After labeling, total lipids were extracted and counted for C-14 by scintillation counting.

Results: Endogenous fatty acid synthetic activities of oral squamous cell caranoma in the cerulenin-treated group decreased by 19% at 1 hour, 64% at 2 hours, and 87/7% at 4 hours; remained nearly unchanged in the dimethylsulfoxide-treated group; and increased slightly in the control group. The oral mucosa tissues were only mildly affected by cerulenin in fatty acid synthesis.

Conclusions: Cerulenin significantly inhibits fatty acid synthetic activity in squamous cell carcinoma and only mildly affected the oral mucosa, indicating that the fatty acid synthetic pathway may be exploited as a target for developing anticancer drugs. (C) 2003 American Association of Oral and Maxillofacial Surgeons.

语种: 英语
WOS记录号: WOS:000184357200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60959
Appears in Collections:北京大学口腔医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Cell Biol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China

Recommended Citation:
Guo, CB,Cui, NB,Yu, GY,et al. Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity[J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2003,61(8):909-912.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guo, CB]'s Articles
[Cui, NB]'s Articles
[Yu, GY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guo, CB]‘s Articles
[Cui, NB]‘s Articles
[Yu, GY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace