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学科主题口腔医学
Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity
Guo, CB; Cui, NB; Yu, GY; Liu, DX; Meng, SC; Song, Q
刊名JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2003-08-01
DOI10.1016/S0278-2391(03)00237-4
61期:8页:909-912
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BREAST-CANCER ; SYNTHASE FAS ; PREDICTOR ; INHIBITION ; RECURRENCE ; DISEASE ; TARGET ; STAGE
英文摘要

Purposes: Inhibition of cerulenin on the endogenous fatty acid synthetic activities of oral squamous cell carcinoma (OSCC) and normal oral mucosa was assayed.

Methods: Squamous cell carcinoma and normal oral mucosa were collected fresh from surgical specimens. The collected tissues were minced in RPMI 1640 and divided into 3 groups: cerulenin treated, dimethylsuffoxide treated, and control. The tissues were incubated in [1(2)-C-14]acetic acid, sodium salt for the last 2.5 hours of the treatment at 37degreesC in 5% CO2. After labeling, total lipids were extracted and counted for C-14 by scintillation counting.

Results: Endogenous fatty acid synthetic activities of oral squamous cell caranoma in the cerulenin-treated group decreased by 19% at 1 hour, 64% at 2 hours, and 87/7% at 4 hours; remained nearly unchanged in the dimethylsulfoxide-treated group; and increased slightly in the control group. The oral mucosa tissues were only mildly affected by cerulenin in fatty acid synthesis.

Conclusions: Cerulenin significantly inhibits fatty acid synthetic activity in squamous cell carcinoma and only mildly affected the oral mucosa, indicating that the fatty acid synthetic pathway may be exploited as a target for developing anticancer drugs. (C) 2003 American Association of Oral and Maxillofacial Surgeons.

语种英语
WOS记录号WOS:000184357200010
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60959
专题北京大学口腔医学院
作者单位1.Peking Univ, Dept Cell Biol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
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GB/T 7714
Guo, CB,Cui, NB,Yu, GY,et al. Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity[J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2003,61(8):909-912.
APA Guo, CB,Cui, NB,Yu, GY,Liu, DX,Meng, SC,&Song, Q.(2003).Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity.JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,61(8),909-912.
MLA Guo, CB,et al."Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity".JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 61.8(2003):909-912.
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