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学科主题: 临床医学
题名:
64-Slice spiral CT perfusion combined with vascular imaging of acute ischemic stroke for assessment of infarct core and penumbra
作者: Bao, Dang-Zhen1; Bao, Huan-Ying1; Yao, Li-Zhai1; Pan, Yun-Gao2; Zhu, Xin-Rui2; Yang, Xiao-Song2; Wang, He3; Huang, Yi-Ning3
关键词: computed tomography ; perfusion ; penumbra ; stroke
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2013-07-01
DOI: 10.3892/etm.2013.1107
卷: 6, 期:1, 页:133-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: ACUTE HEMISPHERIC STROKE ; ANGIOGRAPHY SOURCE IMAGES ; COMPUTED-TOMOGRAPHY ; CEREBRAL-ISCHEMIA ; DIFFUSION ; BRAIN ; DECONVOLUTION ; ASSOCIATION ; EXPERIENCE ; ADMISSION
英文摘要:

The aim of this study was to determine the value of computed tomography perfusion (CTP) parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time-to-peak (TP), in a clinical study of patients with stroke. Additionally, we determined which parameter or combination of parameters are reliable in detecting the presence of an infarct and penumbra. CTP was performed within 24 h of the onset of symptoms in 20 patients with possible stroke. Magnetic resonance imaging (MRI) was performed 3-7 days later and the threshold of the CTP was adjusted according to the results to provide CT images that correlated with the MRI; the MRI results were taken as the gold standard. CBV, CBF and TP contrast agent enhancement were calculated using the CT results. The CTP results were compared with the MRI findings. All CTP parameters were reliable in detecting the penumbra (P<0.001). In these parameters, changes of MTT were the most useful. CTP revealed various changes in CBF, CBV, MTT and TP in ischemic areas. CTP parameters were also reliable in detecting the infarct core (P<0.001). We determined that when detecting the penumbra, all CTP parameters are reliable, and when detecting cerebral ischemia, a combination of parameters should be used.

语种: 英语
WOS记录号: WOS:000321078900026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60960
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Nanle Rehabil Hosp, Dept Neurol, Puyang 457400, Henan, Peoples R China
2.Nanle Cent Hosp, Dept Neurol, Puyang 457400, Henan, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurol & Med Imaging, Beijing 100034, Peoples R China

Recommended Citation:
Bao, Dang-Zhen,Bao, Huan-Ying,Yao, Li-Zhai,et al. 64-Slice spiral CT perfusion combined with vascular imaging of acute ischemic stroke for assessment of infarct core and penumbra[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,6(1):133-139.
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