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学科主题临床医学
Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium
Yin, Hui; He, Qun; Li, Ting; Leong, Anthony S-Y
关键词carcinoma in situ urinary bladder cytokeratin 20 Ki-67 WHO/ISUP classification
刊名APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
2006-09-01
14期:3页:260-265
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]TRANSITIONAL-CELL CARCINOMA ; URINARY-BLADDER ; EXPRESSION ; P53 ; CLASSIFICATION ; TUMORS ; DYSPLASIA ; NEOPLASMS ; PROTEIN ; SOCIETY
英文摘要

Urothelial carcinoma in situ (CIS) is a high-grade neoplasm and an indicator of recurrence and progression that requires specific treatment. The distinction of CIS from flat nonneoplastic urothelium, in particular dysplasia, on the basis of histologic features is often difficult, and this study aims to validate cytokeratin 20 (CK20) and Ki-67 as discriminatory markers for this purpose. Immunostaining of these markers was applied to 26 cases of CIS, 14 atypia of unknown significance, 4 dysplasia, 6 normal, and 9 hyperplastic urothelium. CIS showed CK20 staining of deep urothelial cells in 23/26 CIS compared with restricted staining in surface cells in all non-neoplastic lesions. CIS had significantly increased Ki-67 index with a mean of 53.37% compared with that of non-neoplastic urothelium, which was < 10% (P < 0.0001). The proliferating cells were distributed randomly in CIS, whereas in non-neoplastic urothelium, staining was confined to the basal layer. Among the cases of atypia, 3/14 displayed deep staining for CK20 and 6/14 had elevated Ki-67 counts. In dysplasia similar findings were present in 1/4 and 2/4 cases, respectively. These findings suggest that CK20 and Ki-67 are objective markers to distinguish CIS from non-neoplastic urothelium. In cases of "atypia of unknown significance" and "dysplasia," positivity for both markers should raise the possibility of CIS or preneoplastic change and identify those cases for follow-up.

语种英语
WOS记录号WOS:000240072600002
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60961
专题北京大学第一临床医学院_病理科
作者单位1.Hunter Area Pathol Serv, Newcastle, NSW, Australia
2.Univ Newcastle, Newcastle, NSW 2308, Australia
3.Peking Univ, Hosp 1, Genitourinary Inst, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Genitourinary Inst, Pathol Lab, Beijing 100871, Peoples R China
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Yin, Hui,He, Qun,Li, Ting,et al. Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium[J]. APPLIED IMMUNOHISTOCHEMISTRY &amp; MOLECULAR MORPHOLOGY,2006,14(3):260-265.
APA Yin, Hui,He, Qun,Li, Ting,&Leong, Anthony S-Y.(2006).Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,14(3),260-265.
MLA Yin, Hui,et al."Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium".APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 14.3(2006):260-265.
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