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学科主题: 临床医学
题名:
Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium
作者: Yin, Hui; He, Qun; Li, Ting; Leong, Anthony S-Y
关键词: carcinoma in situ ; urinary bladder ; cytokeratin 20 ; Ki-67 ; WHO/ISUP classification
刊名: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
发表日期: 2006-09-01
卷: 14, 期:3, 页:260-265
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]: TRANSITIONAL-CELL CARCINOMA ; URINARY-BLADDER ; EXPRESSION ; P53 ; CLASSIFICATION ; TUMORS ; DYSPLASIA ; NEOPLASMS ; PROTEIN ; SOCIETY
英文摘要:

Urothelial carcinoma in situ (CIS) is a high-grade neoplasm and an indicator of recurrence and progression that requires specific treatment. The distinction of CIS from flat nonneoplastic urothelium, in particular dysplasia, on the basis of histologic features is often difficult, and this study aims to validate cytokeratin 20 (CK20) and Ki-67 as discriminatory markers for this purpose. Immunostaining of these markers was applied to 26 cases of CIS, 14 atypia of unknown significance, 4 dysplasia, 6 normal, and 9 hyperplastic urothelium. CIS showed CK20 staining of deep urothelial cells in 23/26 CIS compared with restricted staining in surface cells in all non-neoplastic lesions. CIS had significantly increased Ki-67 index with a mean of 53.37% compared with that of non-neoplastic urothelium, which was < 10% (P < 0.0001). The proliferating cells were distributed randomly in CIS, whereas in non-neoplastic urothelium, staining was confined to the basal layer. Among the cases of atypia, 3/14 displayed deep staining for CK20 and 6/14 had elevated Ki-67 counts. In dysplasia similar findings were present in 1/4 and 2/4 cases, respectively. These findings suggest that CK20 and Ki-67 are objective markers to distinguish CIS from non-neoplastic urothelium. In cases of "atypia of unknown significance" and "dysplasia," positivity for both markers should raise the possibility of CIS or preneoplastic change and identify those cases for follow-up.

语种: 英语
WOS记录号: WOS:000240072600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60961
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.Hunter Area Pathol Serv, Newcastle, NSW, Australia
2.Univ Newcastle, Newcastle, NSW 2308, Australia
3.Peking Univ, Hosp 1, Genitourinary Inst, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Genitourinary Inst, Pathol Lab, Beijing 100871, Peoples R China

Recommended Citation:
Yin, Hui,He, Qun,Li, Ting,et al. Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium[J]. APPLIED IMMUNOHISTOCHEMISTRY &amp; MOLECULAR MORPHOLOGY,2006,14(3):260-265.
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