北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科  > 期刊论文
学科主题: 临床医学
题名:
Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions
作者: Liu, Wenhong1; Liu, Ran1; Sun, Wei1; Peng, Qing1; Zhang, Weiwei3; Xu, En4; Cheng, Yan5; Ding, Meiping6; Li, Yansheng7; Hong, Zhen8; Wu, Jiang9; Zeng, Jinsheng10; Yao, Chen2; Huang, Yining1; CASISP Study Grp
关键词: blood pressure variability ; cerebral microbleeds ; hypertension ; white matter lesions
刊名: STROKE
发表日期: 2012-11-01
DOI: 10.1161/STROKEAHA.112.658369
卷: 43, 期:11, 页:2916-U253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]: Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]: TO-VISIT VARIABILITY ; INTRACEREBRAL HEMORRHAGE ; EPISODIC HYPERTENSION ; BRAIN MICROBLEEDS ; ROTTERDAM SCAN ; RATING-SCALE ; RISK-FACTORS ; PREVALENCE ; STROKE ; AGE
英文摘要:

Background and Purpose-Cerebral microbleeds (CMB) and white matter lesions (WML) are cerebral small vessel diseases. Hypertension is considered the most important risk factor. Its mechanism is not yet clarified. Our study assessed the association of blood pressure variability (BPV) with CMB and WML progression.

Methods-Patients with a history of ischemic stroke within 1 to 6 months were consecutively recruited and followed-up for 12 to 18 months. Blood pressure was measured monthly and controlled to a target level. BPV was quantified by the maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of mean, and successive variation independent of mean. Magnetic resonance imaging was performed at baseline and the end of the study. CMB and WML were rated using Microbleed Anatomic Rating Scale and Age-Related White Matter Changes scales, respectively. Multiple logistic analyses assessed BPV associations with CMB and WML development.

Results-Of 720 patients recruited, 500 and 584 had follow-up results for CMB and WML, respectively; 13.2% and 48.1% showed CMB and WML progression, respectively, over a median of 14 months. Patients with CMB had a higher mean, maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of the mean, and successive variation independent of the mean in either systolic blood pressure or diastolic blood pressure (P<0.05). Systolic blood pressure variability was an independent risk factor for deep and infratentorial CMB progression, whereas diastolic blood pressure variability was independently associated with CMB development in deep regions. WML progression was not significantly associated with BPV between visits.

Conclusion-BPV independently predicts CMB progression in deep and infratentorial regions. Clinical Trial Registration Information-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00202020. (Stroke. 2012;43:2916-2922.)

语种: 英语
所属项目编号: 2008ZX09312-017 ; SCW2011-09
项目资助者: National Ministry of Health of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Beijing committee of science and technology
WOS记录号: WOS:000310432800276
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60969
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Biostat, Hosp 1, Beijing 100034, Peoples R China
3.Mil Gen Hosp Beijing PLA, Dept Neurol, Beijing, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou, Guangdong, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin, Peoples R China
6.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310003, Zhejiang, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurol, Shanghai 200030, Peoples R China
8.Fudan Univ, Dept Neurol, Huashan Hosp, Shanghai 200433, Peoples R China
9.Jilin Univ, Hosp 1, Dept Neurol, Changchun 130023, Peoples R China
10.Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
Liu, Wenhong,Liu, Ran,Sun, Wei,et al. Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions[J]. STROKE,2012,43(11):2916-U253.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Wenhong]'s Articles
[Liu, Ran]'s Articles
[Sun, Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Wenhong]‘s Articles
[Liu, Ran]‘s Articles
[Sun, Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace