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学科主题临床医学
Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions
Liu, Wenhong1; Liu, Ran1; Sun, Wei1; Peng, Qing1; Zhang, Weiwei3; Xu, En4; Cheng, Yan5; Ding, Meiping6; Li, Yansheng7; Hong, Zhen8; Wu, Jiang9; Zeng, Jinsheng10; Yao, Chen2; Huang, Yining1; CASISP Study Grp
关键词blood pressure variability cerebral microbleeds hypertension white matter lesions
刊名STROKE
2012-11-01
DOI10.1161/STROKEAHA.112.658369
43期:11页:2916-U253
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]TO-VISIT VARIABILITY ; INTRACEREBRAL HEMORRHAGE ; EPISODIC HYPERTENSION ; BRAIN MICROBLEEDS ; ROTTERDAM SCAN ; RATING-SCALE ; RISK-FACTORS ; PREVALENCE ; STROKE ; AGE
英文摘要

Background and Purpose-Cerebral microbleeds (CMB) and white matter lesions (WML) are cerebral small vessel diseases. Hypertension is considered the most important risk factor. Its mechanism is not yet clarified. Our study assessed the association of blood pressure variability (BPV) with CMB and WML progression.

Methods-Patients with a history of ischemic stroke within 1 to 6 months were consecutively recruited and followed-up for 12 to 18 months. Blood pressure was measured monthly and controlled to a target level. BPV was quantified by the maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of mean, and successive variation independent of mean. Magnetic resonance imaging was performed at baseline and the end of the study. CMB and WML were rated using Microbleed Anatomic Rating Scale and Age-Related White Matter Changes scales, respectively. Multiple logistic analyses assessed BPV associations with CMB and WML development.

Results-Of 720 patients recruited, 500 and 584 had follow-up results for CMB and WML, respectively; 13.2% and 48.1% showed CMB and WML progression, respectively, over a median of 14 months. Patients with CMB had a higher mean, maximum, standard deviation, coefficient of variation, successive variation, standard deviation independent of the mean, and successive variation independent of the mean in either systolic blood pressure or diastolic blood pressure (P<0.05). Systolic blood pressure variability was an independent risk factor for deep and infratentorial CMB progression, whereas diastolic blood pressure variability was independently associated with CMB development in deep regions. WML progression was not significantly associated with BPV between visits.

Conclusion-BPV independently predicts CMB progression in deep and infratentorial regions. Clinical Trial Registration Information-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00202020. (Stroke. 2012;43:2916-2922.)

语种英语
WOS记录号WOS:000310432800276
项目编号2008ZX09312-017 ; SCW2011-09
资助机构National Ministry of Health of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Beijing committee of science and technology
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60969
专题北京大学第一临床医学院_神经内科
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Biostat, Hosp 1, Beijing 100034, Peoples R China
3.Mil Gen Hosp Beijing PLA, Dept Neurol, Beijing, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou, Guangdong, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin, Peoples R China
6.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310003, Zhejiang, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurol, Shanghai 200030, Peoples R China
8.Fudan Univ, Dept Neurol, Huashan Hosp, Shanghai 200433, Peoples R China
9.Jilin Univ, Hosp 1, Dept Neurol, Changchun 130023, Peoples R China
10.Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Liu, Wenhong,Liu, Ran,Sun, Wei,et al. Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions[J]. STROKE,2012,43(11):2916-U253.
APA Liu, Wenhong.,Liu, Ran.,Sun, Wei.,Peng, Qing.,Zhang, Weiwei.,...&CASISP Study Grp.(2012).Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions.STROKE,43(11),2916-U253.
MLA Liu, Wenhong,et al."Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions".STROKE 43.11(2012):2916-U253.
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