IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Surgical left cardiac sympathetic denervation for long QT syndrome: effects on QT interval and heart rate
Li, CL; Hu, DY; Shang, LH; Ma, S; Liu, WL; Li, YT; Ma, ZM; Tang, CZ; Mei, YQ; Wang, LX
关键词long QT syndrome left cardiac sympathetic denervation QT interval arrhythmia cardiac electrophysiology
刊名HEART AND VESSELS
2005-07-01
DOI10.1007/s00380-005-0820-1
20期:4页:137-141
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]Q-T SYNDROME ; THERAPY ; STELLECTOMY ; MANAGEMENT ; DOGS
英文摘要

The primary aim of the present study was to investigate the short-term effects of surgical left cardiac sympathetic denervation (LCSD) on the QT interval and heart rate in patients with congenital long QT syndrome (LQTS). Left cardiac sympathetic denervation was performed in five LQTS patients who had a history of syncope. The patients′ 12-lead and 24-h Holter monitoring ECG was recorded 24 h before and 24 h after LCSD. Treadmill exercise tests were also performed before and 6 days after surgery to assess changes in heart rate and the QT interval after surgery. Left cardiac sympathetic denervation was successful in all patients. The mean value of the corrected QT interval (QTc) in the five patients decreased from 0.59 +/- 0.05 to 0.48 +/- 0.04 s (P = 0.006) immediately after the procedure and remained short (0.47 +/- 0.04, P < 0.05) after a 21-month follow-up. The mean value of QTc on the 24-h Holter monitoring ECG also decreased in all patients (0.67 +/- 0.07 vs 0.60 +/- 0.05 s, P < 0.01). The mean, maximum, and minimum heart rate on the 24-h ECG remained unchanged (P > 0.05). The maximum heart rate during the exercise tests decreased from 162 +/- 4 beats/min before surgery to 129 +/- 10 beats/min (P < 0.01). The exercise-induced increase in QTc remained unchanged after the surgery (P > 0.05). Although four of the five patients were syncope-free until 21 months postoperatively, the remaining patient had a recurrence of syncope, requiring an increased dose of beta blocker. These findings indicate that LCSD shortens QTc and diminishes the exercise-induced increase in heart rate whereas the resting heart rate and exercise-induced increase in QTc remain unchanged. These results may have implications for the effectiveness and limitations of LCSD.

语种英语
WOS记录号WOS:000230565700002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60970
专题北京大学第二临床医学院_心血管内科
作者单位1.Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2678, Australia
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
3.Tongren Hosp, Ctr Heart, Beijing, Peoples R China
4.Tongren Hosp, Dept Thorac Surg, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, CL,Hu, DY,Shang, LH,et al. Surgical left cardiac sympathetic denervation for long QT syndrome: effects on QT interval and heart rate[J]. HEART AND VESSELS,2005,20(4):137-141.
APA Li, CL.,Hu, DY.,Shang, LH.,Ma, S.,Liu, WL.,...&Wang, LX.(2005).Surgical left cardiac sympathetic denervation for long QT syndrome: effects on QT interval and heart rate.HEART AND VESSELS,20(4),137-141.
MLA Li, CL,et al."Surgical left cardiac sympathetic denervation for long QT syndrome: effects on QT interval and heart rate".HEART AND VESSELS 20.4(2005):137-141.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, CL]的文章
[Hu, DY]的文章
[Shang, LH]的文章
百度学术
百度学术中相似的文章
[Li, CL]的文章
[Hu, DY]的文章
[Shang, LH]的文章
必应学术
必应学术中相似的文章
[Li, CL]的文章
[Hu, DY]的文章
[Shang, LH]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。