|Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients|
|Lu, Qian1,2,3; Cheng, Li-Tao2; Wang, Tao2; Wan, Jie3; Liao, Lan-Lau3; Zeng, Jing2; Qin, Chao2; Li, Ke-Ji1|
|刊名||JOURNAL OF RENAL NUTRITION|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics ; Urology & Nephrology|
|研究领域[WOS]||Nutrition & Dietetics ; Urology & Nephrology|
|关键词[WOS]||BIOELECTRICAL-IMPEDANCE ANALYSIS ; PULSE-WAVE VELOCITY ; STAGE RENAL-DISEASE ; DEPENDENT DIABETES-MELLITUS ; INSULIN-RESISTANCE ; MEDIATED VASODILATION ; VASCULAR REACTIVITY ; NUTRITIONAL-STATUS ; BODY-COMPOSITION ; RISK-FACTORS|
Background: The relationship between overweight or obesity and mortality in peritoneal dialysis (PD) patients remains controversial. Both pulse-wave velocity (PWV) and endothelial dysfunction are related to an increased risk of cardiovascular disease. However, the association between PWV, endothelial dysfunction, and visceral adipose tissue in PD patients is not well-understood.
Methods: One hundred and sixteen PD patients were enrolled in this cross-sectional study. The overall fat ratio and visceral-fat level of PD patients were measured by multiple-frequency bioelectrical impedance analysis (BIA). Carotid-femoral pulse-wave velocity (C-F PWV) was measured as an indicator of aortic stiffness. Endothelial function was evaluated by brachial-artery flow-mediated dilation (FMD). The association between these monitored parameters was assessed by statistical analyses.
Results: Bivariate correlation analysis showed that C-F PWV was positively correlated with visceral-fat level (r = 0.343, P < .001), whereas FMD was negatively correlated with visceral-fat level (r = -0.354, P < .01). Multiple regression analysis indicated that age, diabetic status, visceral-fat level, and duration of dialysis were determinants of PWV (adjusted R-2 = 0.316, P < .001), whereas visceral-fat level and glucose load were the determinants of FMD (adjusted R-2 = 0.130, P < .01).
Conclusion: Visceral-fat level was an independent predictor of PWV and FMD in PD patients, and could be considered one of the risk factors for cardiovascular disease in PD patients. Crown Copyright (C) 2008 Published by the National Kidney Foundation, Inc. All rights reserved.
|项目编号||36-1 ; 38-18 ; BSD-06-5-24 ; YLZD 06-5-27|
|资助机构||Cheung Kong Scholar Program ; Ministry of Education, People&prime ; s Republic of China ; Peking University EBM Group ; Doctorial Degree Fund ; Clinical Research Program ; Peking University Third Hospital|
|作者单位||1.Peking Univ, Sch Nursing, Beijing 100083, Peoples R China|
2.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China
|Lu, Qian,Cheng, Li-Tao,Wang, Tao,et al. Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients[J]. JOURNAL OF RENAL NUTRITION,2008,18(6):495-502.|
|APA||Lu, Qian.,Cheng, Li-Tao.,Wang, Tao.,Wan, Jie.,Liao, Lan-Lau.,...&Li, Ke-Ji.(2008).Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients.JOURNAL OF RENAL NUTRITION,18(6),495-502.|
|MLA||Lu, Qian,et al."Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients".JOURNAL OF RENAL NUTRITION 18.6(2008):495-502.|
|Lu_et_alVisceral Fat（201KB）||期刊论文||作者接受稿||开放获取||CC BY-NC-SA||浏览 请求全文|