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学科主题: 公共卫生
题名:
Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients
作者: Lu Qian(路潜)1,2,3; Cheng, Li-Tao2; Wang, Tao2; Wan, Jie3; Liao, Lan-Lau3; Zeng, Jing2; Qin, Chao2; Li, Ke-Ji1
刊名: JOURNAL OF RENAL NUTRITION
发表日期: 2008-11-01
DOI: 10.1053/j.jrn.2008.05.006
卷: 18, 期:6, 页:495-502
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics ; Urology & Nephrology
研究领域[WOS]: Nutrition & Dietetics ; Urology & Nephrology
关键词[WOS]: BIOELECTRICAL-IMPEDANCE ANALYSIS ; PULSE-WAVE VELOCITY ; STAGE RENAL-DISEASE ; DEPENDENT DIABETES-MELLITUS ; INSULIN-RESISTANCE ; MEDIATED VASODILATION ; VASCULAR REACTIVITY ; NUTRITIONAL-STATUS ; BODY-COMPOSITION ; RISK-FACTORS
英文摘要:

Background: The relationship between overweight or obesity and mortality in peritoneal dialysis (PD) patients remains controversial. Both pulse-wave velocity (PWV) and endothelial dysfunction are related to an increased risk of cardiovascular disease. However, the association between PWV, endothelial dysfunction, and visceral adipose tissue in PD patients is not well-understood.

Methods: One hundred and sixteen PD patients were enrolled in this cross-sectional study. The overall fat ratio and visceral-fat level of PD patients were measured by multiple-frequency bioelectrical impedance analysis (BIA). Carotid-femoral pulse-wave velocity (C-F PWV) was measured as an indicator of aortic stiffness. Endothelial function was evaluated by brachial-artery flow-mediated dilation (FMD). The association between these monitored parameters was assessed by statistical analyses.

Results: Bivariate correlation analysis showed that C-F PWV was positively correlated with visceral-fat level (r = 0.343, P < .001), whereas FMD was negatively correlated with visceral-fat level (r = -0.354, P < .01). Multiple regression analysis indicated that age, diabetic status, visceral-fat level, and duration of dialysis were determinants of PWV (adjusted R-2 = 0.316, P < .001), whereas visceral-fat level and glucose load were the determinants of FMD (adjusted R-2 = 0.130, P < .01).

Conclusion: Visceral-fat level was an independent predictor of PWV and FMD in PD patients, and could be considered one of the risk factors for cardiovascular disease in PD patients. Crown Copyright (C) 2008 Published by the National Kidney Foundation, Inc. All rights reserved.

语种: 英语
所属项目编号: 36-1 ; 38-18 ; BSD-06-5-24 ; YLZD 06-5-27
项目资助者: Cheung Kong Scholar Program ; Ministry of Education, People&prime ; s Republic of China ; Peking University EBM Group ; Doctorial Degree Fund ; Clinical Research Program ; Peking University Third Hospital
WOS记录号: WOS:000260916300004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60973
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Nursing, Beijing 100083, Peoples R China
2.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China

Recommended Citation:
Lu, Qian,Cheng, Li-Tao,Wang, Tao,et al. Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients[J]. JOURNAL OF RENAL NUTRITION,2008,18(6):495-502.
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