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学科主题: 临床医学
题名:
Reactive Oxygen Species Alteration of Immune Cells in Local Residents at an Electronic Waste Recycling Site in Northern China
作者: Li, Ran1,2; Yang, Qiaoyun1,2; Qiu, Xinghua1,2; Li, Keqiu3; Li, Guang3; Zhu, Ping4; Zhu, Tong1,2
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2013-04-02
DOI: 10.1021/es400027v
卷: 47, 期:7, 页:3344-3352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; POLYCHLORINATED-BIPHENYLS PCBS ; PERSISTENT ORGANIC POLLUTANTS ; DIBENZO-P-DIOXINS ; RESPIRATORY BURST ; EXPOSURE ; ACTIVATION ; MECHANISMS ; STRESS ; PBDES
英文摘要:

The health effects of exposure to pollutants from electronic waste (e-waste) pose an important issue. In this study, we explored the association between oxidative stress and blood levels of e-waste-related pollutants. Blood samples were collected from individuals living in the proximity of an e-waste recycling site located in northern China, and pollutants, as well as reactive oxygen species (ROS), were measured in comparison to a reference population. The geometric mean concentrations of PCBs, dechlorane plus, and 2,2′,4,4′,5,5′-hexabromobiphenyl in plasma from the exposure group were 60.4, 9.0, and 0.55 ng g(-1) lipid, respectively, which were 2.2, 3.2, and 2.2 times higher than the corresponding measurement in the reference group. Correspondingly, ROS levels in white blood cells, including in neutrophil granulocytes, from the exposure group were significantly higher than in those from the reference group, suggesting potential ROS related health effects for residents at the e-waste site. In contrast, fewer ROS were generated in the respiratory burst of neutrophil granulocytes for the exposure group, indicating a depressed innate immune function for the individuals living at the e-waste site. These findings suggest a potential linkage between exposure to pollutants from e-waste recycling and both elevated oxidative stress and altered immune function.

语种: 英语
所属项目编号: 21077004 ; 41121004 ; 21190051 ; 21177091
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000317173100043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60977
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
3.Tianjin Med Univ, Basic Med Coll, Tianjin 300070, Peoples R China
4.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China

Recommended Citation:
Li, Ran,Yang, Qiaoyun,Qiu, Xinghua,et al. Reactive Oxygen Species Alteration of Immune Cells in Local Residents at an Electronic Waste Recycling Site in Northern China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2013,47(7):3344-3352.
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