|Gender and risk factor dependence of cerebral blood flow velocity in Chinese adults|
|Zhang, PH; Huang, YN; Li, Y; Shi, P; Lu, M; Detrano, R; Wu, YF|
|关键词||ultrasonography trans-cranial Doppler cerebral arteries blood flow velocity risk factors|
|刊名||BRAIN RESEARCH BULLETIN|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Neurosciences & Neurology|
|关键词[WOS]||MAGNETIC-RESONANCE ANGIOGRAPHY ; CAROTID-ARTERY STENOSIS ; CORONARY-HEART-DISEASE ; TRANSCRANIAL DOPPLER ; INTRACRANIAL STENOSIS ; ISCHEMIC-STROKE ; HYPERTENSION ; ULTRASOUND ; OCCLUSION ; VALUES|
Background and purpose: The objective of this study is to determine if and how cerebral blood flow velocity and stroke risk factors are related in a stroke free population.
Methods: This cross-sectional study recruited 1323 stroke-free subjects, aged 42-73 years, from a county region in China. Systolic blood flow velocities in cerebral arteries were detected with trans-cranial Doppler. Key factors, such as anthropometry, life-style, medication use, blood pressure and blood biochemical analysis were investigated at the same time.
Results: In women, even controlled for major cardiovascular risk factors, cerebral blood flow velocities of common carotid artery, internal carotid artery, middle cerebral artery, anterior cerebral artery and posterior cerebral arteries decreased significantly with age (from 43.8 to 39.3, 48.0 to 42.6, 97.7 to 82.8, 79.2 to 69.4 and 44.1 to 39.7 cm/s in the range of 42-73 years old, p < 0.01 for each). In men, however, this inverse trend only existed in common carotid artery (from 45.6 to 41.7 cm/s, p < 0.01). Multivariate regression showed that most established cardiovascular risk factors (e.g. hypertension, hypercholesterolemia, diabetes mellitus and overweight/obesity) were associated with decreased blood flow velocity in the extra-cranial arteries. However, this association was not present (e.g. diabetes and overweight/obesity) or was inversed (e.g. hypertension and hypercholesterolemia) in the intra-cranial arteries.
Conclusion: Extra-cranial blood flow velocity is significantly and inversely related to age and cardiovascular risk factors. The relationship between intra-cranial blood flow and risk factors changes and may depend on gender. These finding may have importance in the determination of mechanisms of stroke. (c) 2006 Elsevier Inc. All rights reserved.
|作者单位||1.Chinese Acad Med Sci, Dept Epidemiol, Cardiovasc Inst, Beijing 100037, Peoples R China|
2.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
4.Ctr Dis Control & Prevent, Dept Hlth Educ, Beijing 100043, Peoples R China
5.Univ Calif Los Angeles, Sch Med, Harbor UCLA Med Ctr, Torrance, CA 90609 USA
|Zhang, PH,Huang, YN,Li, Y,et al. Gender and risk factor dependence of cerebral blood flow velocity in Chinese adults[J]. BRAIN RESEARCH BULLETIN,2006,69(3):282-287.|
|APA||Zhang, PH.,Huang, YN.,Li, Y.,Shi, P.,Lu, M.,...&Wu, YF.(2006).Gender and risk factor dependence of cerebral blood flow velocity in Chinese adults.BRAIN RESEARCH BULLETIN,69(3),282-287.|
|MLA||Zhang, PH,et al."Gender and risk factor dependence of cerebral blood flow velocity in Chinese adults".BRAIN RESEARCH BULLETIN 69.3(2006):282-287.|