北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Rationale and design of China intensive lipid lowering with statins in acute coronary syndrome: The CHILLAS study
作者: Zhao, Shui-ping1; Peng, Dao-quan1; Yu, Bi-lian1; Huo, Yong2; CHILLAS Investigators
刊名: AMERICAN HEART JOURNAL
发表日期: 2009-10-01
DOI: 10.1016/j.ahj.2009.07.030
卷: 158, 期:4, 页:509-U1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: HIGH-DOSE ATORVASTATIN ; CONTROLLED TRIAL ; CHOLESTEROL ; DISEASE ; EVENTS ; SIMVASTATIN ; PRAVASTATIN ; PREVENTION
英文摘要:

Background Current guidelines recommended intensive low-density lipoprotein cholesterol lowering with statins, aiming at the target of 70 mg/dL (1.81 mmol/L) of low-density lipoprotein cholesterol for those with very high risk of coronary artery events. However, there is no multicenter study assessing the effect of intensive lipid lowering therapy with statins on acute coronary syndrome (ACS) in Chinese population.

Methods An open-label multicenter study is planned to evaluate whether intensive treatment with statins for 2 to 5 years results in more reduction of cardiovascular events in patients with ACS compared to the standard statin therapy. A total of 1,600 patients will be randomly assigned to receive intensive statin therapy (atorvastatin, 20 or 40 mg/d, or equivalent dose of other statins) or standard statin therapy (atorvastatin, 10 mg/d, or equivalent dose of other statins). Both groups will receive dietary counseling. Over the follow-up period, the primary outcome measure is the time to occurrence of cardiac death, nonfatal acute myocardial infarction, revascularization with either percutaneous coronary intervention or coronary-artery bypass grafting, documented unstable angina or severe heart failure requiring emergency hospitalization, and stroke. The planned duration for enrollment is between December 2006 and December 2009.

Conclusions The CHILLAS study will be the first multicenter study in a Chinese population using a patient-level analysis to compare the effects and safety of intensive statin therapy with that of standard-dose statin therapy, which may provide new evidence and therapeutic standards for the treatment of ACS. (Am Heart J 2009; 158:509-12.)

语种: 英语
WOS记录号: WOS:000270706100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60981
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Shui-ping,Peng, Dao-quan,Yu, Bi-lian,et al. Rationale and design of China intensive lipid lowering with statins in acute coronary syndrome: The CHILLAS study[J]. AMERICAN HEART JOURNAL,2009,158(4):509-U1.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Shui-ping]'s Articles
[Peng, Dao-quan]'s Articles
[Yu, Bi-lian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Shui-ping]‘s Articles
[Peng, Dao-quan]‘s Articles
[Yu, Bi-lian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace