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Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas
Liu, De-Bin1; Gu, Zhen-Dong1; Cao, Xiao-Zhe2; Liu, Hong1; Li, Ji-You3
关键词Esophageal squamous cell carcinoma Homeobox genes Homeodomain HoxD9 Pbx1
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2005-03-14
11期:10页:1562-1566
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

To evaluate the expression pattern of two novel oncofetal antigens, the HoxD9 and Pbx1 homeoproteins in esophageal squamous cell carcinomas (ESCCs) to determine what role they would play in the carcinogenesis of ESCC.

METHODS: We obtained tissue samples of ESCC from 56 patients who underwent esophagectomy but not preoperative chemotherapy or radiotherapy. The diagnosis of ESCC was established and confirmed by staff pathologists. We used a highly sensitive, indirect, immunocytochemical method to detect HoxD9 and PbX1 proteins. We qualitatively and quantitively evaluated cells that exhibited and staining using a light microscope.

RESULTS: In all observed carcinoma tissue samples, more than 60% of neoplastic cells stained lightly or strongly for HoxD9, and more than 50% of neoplastic cells stained lightly or strongly for Pbx1.

CONCLUSION: Our data suggest that HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer new avenues for treatment of this disease. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000208102200026
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60983
专题北京大学临床肿瘤学院_胸外科
作者单位1.Peking Univ Sch Oncol, Dept Thorac Surg, Beijing Canc Hosp, Beijing Inst Canc Res, Beijing 100036, Peoples R China
2.PLA, Lanzhou Gen Hosp, Dept Pathol, Lanzhou 730030, Gansu, Peoples R China
3.Peking Univ Sch Oncol, Dept Pathol, Beijing Canc Hosp, Beijing Inst Canc Res, Beijing 100036, Peoples R China
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GB/T 7714
Liu, De-Bin,Gu, Zhen-Dong,Cao, Xiao-Zhe,et al. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(10):1562-1566.
APA Liu, De-Bin,Gu, Zhen-Dong,Cao, Xiao-Zhe,Liu, Hong,&Li, Ji-You.(2005).Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas.WORLD JOURNAL OF GASTROENTEROLOGY,11(10),1562-1566.
MLA Liu, De-Bin,et al."Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas".WORLD JOURNAL OF GASTROENTEROLOGY 11.10(2005):1562-1566.
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