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学科主题: 临床医学
题名:
Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas
作者: Liu, De-Bin1; Gu, Zhen-Dong1; Cao, Xiao-Zhe2; Liu, Hong1; Li, Ji-You3
关键词: Esophageal squamous cell carcinoma ; Homeobox genes ; Homeodomain ; HoxD9 ; Pbx1
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2005-03-14
卷: 11, 期:10, 页:1562-1566
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

To evaluate the expression pattern of two novel oncofetal antigens, the HoxD9 and Pbx1 homeoproteins in esophageal squamous cell carcinomas (ESCCs) to determine what role they would play in the carcinogenesis of ESCC.

METHODS: We obtained tissue samples of ESCC from 56 patients who underwent esophagectomy but not preoperative chemotherapy or radiotherapy. The diagnosis of ESCC was established and confirmed by staff pathologists. We used a highly sensitive, indirect, immunocytochemical method to detect HoxD9 and PbX1 proteins. We qualitatively and quantitively evaluated cells that exhibited and staining using a light microscope.

RESULTS: In all observed carcinoma tissue samples, more than 60% of neoplastic cells stained lightly or strongly for HoxD9, and more than 50% of neoplastic cells stained lightly or strongly for Pbx1.

CONCLUSION: Our data suggest that HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer new avenues for treatment of this disease. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 954813600 ; H020920030390
项目资助者: Beijing Municipal Science and Technology Commission ; Peking University School of Oncology, Beijing Cancer Hospital
WOS记录号: WOS:000208102200026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60983
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Peking Univ Sch Oncol, Dept Thorac Surg, Beijing Canc Hosp, Beijing Inst Canc Res, Beijing 100036, Peoples R China
2.PLA, Lanzhou Gen Hosp, Dept Pathol, Lanzhou 730030, Gansu, Peoples R China
3.Peking Univ Sch Oncol, Dept Pathol, Beijing Canc Hosp, Beijing Inst Canc Res, Beijing 100036, Peoples R China

Recommended Citation:
Liu, De-Bin,Gu, Zhen-Dong,Cao, Xiao-Zhe,et al. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(10):1562-1566.
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