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学科主题: 临床医学
题名:
Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis
作者: Xie, Qian; Zhang, Ai-Hua; Chen, Shao-Yan; Lai, Xuan; Zhang, Feng; He, Lian; Zhuang, Zhen; Zhu, Ning; Fan, Min-Hua; Wang, Tao
关键词: Metabolic syndrome ; Nutrition ; Risk factors ; All-cause mortality ; Cardiovascular disease
刊名: ARCHIVES OF CARDIOVASCULAR DISEASES
发表日期: 2012-04-01
DOI: 10.1016/j.acvd.2012.01.012
卷: 105, 期:4, 页:211-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: MAINTENANCE HEMODIALYSIS ; BLOOD-PRESSURE ; RISK ; HOSPITALIZATION ; MALNUTRITION ; INFLAMMATION ; METAANALYSIS ; PREDICTOR ; MORBIDITY ; EVENTS
英文摘要:

Background. - Metabolic syndrome increases the risk of cardiovascular disease (CVD) and all-cause mortality in the general population.

Aims. - To investigate whether metabolic syndrome affects CVD and all-cause mortality in chronic haemodialysis patients.

Methods. - This prospective, observational cohort study was carried out at Peking university third hospital from June 2006 to June 2010. Baseline anthropometric and laboratory parameters were evaluated, and causes and times of mortality were documented. Nutritional status of the patients was assessed using subject global assessment (SGA) and serum albumin levels.

Results. - Of 162 haemodialysis patients recruited, five were lost to follow-up, leaving 157 in the final cohort, who were followed for 36-42 months. Mean age was 62 +/- 11 years and 55.4% were men. F(o)rty-six patients (30%) had metabolic syndrome. In the metabolic syndrome versus the non-metabolic syndrome group, there were fewer patients with malnutrition (by SGA) (15.2% vs. 55.0%; P < 0.001), but there were no significant differences in CVD mortality (8.7% vs. 10.8%; P = 0.9) or all-cause mortality (15.2% vs. 22.5%; P = 0.39), nor in mean observed survival time (30.8 +/- 7.3 vs. 29.8 +/- 8.5 months; P = 0.49) or total survival time (67 +/- 43 vs. 78 +/- 48 months; P = 0.20). Cox regression analysis showed that independent mortality risk factors were pre-existing CVD, age more than or equal to 66 years and serum albumin less than 37 g/L (indicating malnutrition).

Conclusion. - Metabolic syndrome was associated with a better nutritional status, but not with CVD or all-cause mortality in the haemodialysis patients in this prospective cohort study. (C) 2012 Elsevier Masson SAS. All rights reserved.

语种: 英语
WOS记录号: WOS:000305872000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60987
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Xie, Qian,Zhang, Ai-Hua,Chen, Shao-Yan,et al. Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis[J]. ARCHIVES OF CARDIOVASCULAR DISEASES,2012,105(4):211-217.
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