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学科主题: 基础医学
题名:
URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis
作者: Wang, Lan1,2,3; Deng, Weiwei1; Shi, Taiping1,2,3; Ma, Dalong1,2,3
关键词: URP2SF ; NF-kappa B ; transcriptional repressor ; apoptosis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-04-18
DOI: 10.1016/j.bbrc.2008.02.024
卷: 368, 期:4, 页:899-906
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CELL-MATRIX ADHESION ; COLON-CANCER-CELLS ; TRANSCRIPTION FACTOR ; ALPHA-KINASE ; MEMBRANE ; INACTIVATION ; INHIBITION ; ACTIVATION ; GROWTH ; DEATH
英文摘要:

The transcription factor NF-kappa B plays an important role in inflammation and cell survival. Here, we report the functional characterization of URP2SF (UNC-112 related protein 2 short form), which is a novel protein containing FERM and PH domains. The protein is conserved in evolution across different species. Northern blot and RT-PCR analysis revealed that the expression of URP2SF appeared to be primarily confined to immune system. URP2SF protein localized to the whole cell. Over-expression of URP2SF strongly repressed NF-kappa B activity in the absence or presence of NF-kappa B stimulus. Importantly, URP2SF over-expression also induced cell apoptosis. Furthermore, suppression of URP2SF expression by small interference RNA significantly activated the NF-kappa B reporter gene activities, as well as attenuated TNF-alpha induced apoptosis. Therefore, our data show for the first time that URP2SF may act as a transcriptional repressor in NF-kappa B signaling pathway and regulate cell apoptotic pathway. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000254106700011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60993
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Lan,Deng, Weiwei,Shi, Taiping,et al. URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,368(4):899-906.
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