IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis
Wang, Lan1,2,3; Deng, Weiwei1; Shi, Taiping1,2,3; Ma, Dalong1,2,3
关键词URP2SF NF-kappa B transcriptional repressor apoptosis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2008-04-18
DOI10.1016/j.bbrc.2008.02.024
368期:4页:899-906
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CELL-MATRIX ADHESION ; COLON-CANCER-CELLS ; TRANSCRIPTION FACTOR ; ALPHA-KINASE ; MEMBRANE ; INACTIVATION ; INHIBITION ; ACTIVATION ; GROWTH ; DEATH
英文摘要

The transcription factor NF-kappa B plays an important role in inflammation and cell survival. Here, we report the functional characterization of URP2SF (UNC-112 related protein 2 short form), which is a novel protein containing FERM and PH domains. The protein is conserved in evolution across different species. Northern blot and RT-PCR analysis revealed that the expression of URP2SF appeared to be primarily confined to immune system. URP2SF protein localized to the whole cell. Over-expression of URP2SF strongly repressed NF-kappa B activity in the absence or presence of NF-kappa B stimulus. Importantly, URP2SF over-expression also induced cell apoptosis. Furthermore, suppression of URP2SF expression by small interference RNA significantly activated the NF-kappa B reporter gene activities, as well as attenuated TNF-alpha induced apoptosis. Therefore, our data show for the first time that URP2SF may act as a transcriptional repressor in NF-kappa B signaling pathway and regulate cell apoptotic pathway. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000254106700011
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60993
专题北京大学基础医学院_免疫学系
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
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Wang, Lan,Deng, Weiwei,Shi, Taiping,et al. URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,368(4):899-906.
APA Wang, Lan,Deng, Weiwei,Shi, Taiping,&Ma, Dalong.(2008).URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,368(4),899-906.
MLA Wang, Lan,et al."URP2SF, a FERM and PH domain containing protein, regulates NF-kappa B and apoptosis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 368.4(2008):899-906.
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