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学科主题: 临床医学
题名:
Low-dose methotrexate for the treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
作者: Huang, XJ; Jiang, Q; Chen, H; Xu, L; Liu, D; Chen, Y; Han, W; Zhang, Y; Liu, K; Lu, D
关键词: hematopoietic stem cell transplantation ; allogeneic ; methotrexate ; graft-versus-host disease
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2005-08-01
DOI: 10.1038/sj.bmt.1705034
卷: 36, 期:4, 页:343-348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; SALVAGE THERAPY ; CYCLOSPORINE ; PREDNISONE ; MODERATE
英文摘要:

Methotrexate (MTX) is commonly used in the prophylaxis of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT). In order to evaluate the efficacy and safety of low-dose MTX treatment in patients with GVHD after allo-HSCT, 38 patients with acute GVHD (aGVHD), chronic GVHD (cGVHD) or GVHD post-donor lymphocyte infusion (post-DLI GVHD) after allo-HSCT received intravenous MTX at a dose of 5 or 10mg every 5-7 days until a complete or partial response was seen, or there was treatment failure or intolerable side effects. The overall response rate was 94.7% (18/19 patients) in patients with aGVHD, 76.2% (16/21 patients) in patients with cGVHD and 2/2 in patients with post-DLI GVHD. The response rate for GVHD involving various organs was 100% in skin, 75% in gut, 55.6% in liver, 75% in mouth and 100% in the eye, among all enrolled patients. Side effects were minor. Short-term, low-dose MTX is a tolerable and an effective regimen for patients with aGVHD, cGVHD or post-DLI GVHD after allo-HSCT.

语种: 英语
WOS记录号: WOS:000230895400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60995
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, People Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Huang, XJ,Jiang, Q,Chen, H,et al. Low-dose methotrexate for the treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation[J]. BONE MARROW TRANSPLANTATION,2005,36(4):343-348.
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