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学科主题: 临床医学
题名:
Growth differentiation factor 15 in different stages of heart failure: potential screening implications
作者: Wang, Fangfang1,2; Guo, Yanhong1,2; Yu, Haiyi1,2; Zheng, Lingbing1,2; Mi, Lin1,2; Gao, Wei1,2
关键词: Growth differentiation factor 15 ; heart failure ; biomarkers
刊名: BIOMARKERS
发表日期: 2010-12-01
DOI: 10.3109/1354750X.2010.510580
卷: 15, 期:8, 页:671-676
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: LEFT-VENTRICULAR HYPERTROPHY ; NATRIURETIC PEPTIDES ; SYSTOLIC DYSFUNCTION ; BETA SUPERFAMILY ; MANAGEMENT ; GUIDELINES ; HYPERTENSION ; ASSOCIATION ; DIAGNOSIS ; PLASMA
英文摘要:

Identification of individuals in the early stage of heart failure (HF) may allow earlier initiation of disease-modifying treatment. We evaluated concentrations of the growth differentiation factor (GDF)-15at different stages and its potential screening value in 208 subjects. Plasma GDF-15 was measured by using an enzyme-linked immunosorbent assay. GDF-15 was positively correlated with the stages of HF (r=0.804, p < 0.001). In distinguishing patients with stage B HF, the area under the curve was 0.873 (p < 0.001). These findings indicate that GDF-15 concentration was elevated with the progressing stages of HFand might have potential screening implications for stage B HF.

语种: 英语
所属项目编号: 2007cb512107
项目资助者: National Basic Research Program of the PR China
WOS记录号: WOS:000284218800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60996
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Fangfang,Guo, Yanhong,Yu, Haiyi,et al. Growth differentiation factor 15 in different stages of heart failure: potential screening implications[J]. BIOMARKERS,2010,15(8):671-676.
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