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Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to Co-60
Zhang, Jiali; Yu, Yongchao; Zhang, Zhaofeng; Ding, Ye; Dai, Xiaogian; Li, Yong
关键词Cordyceps sinensis Immunomodulator Anti-oxidation
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
2011-12-01
DOI10.1016/j.intimp.2011.09.019
11期:12页:2251-2257
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Pharmacology & Pharmacy
资助者Nutrition and Food Hygiene Department, Peking University ; Nutrition and Food Hygiene Department, Peking University
研究领域[WOS]Immunology ; Pharmacology & Pharmacy
关键词[WOS]HUMAN ENDOTHELIAL-CELLS ; TUMOR-BEARING MICE ; GENE-EXPRESSION ; IL-8 PRODUCTION ; IN-VITRO ; RADIATION ; CYTOKINES ; MEDICINE ; MACROPHAGES ; LYMPHOCYTES
英文摘要

Aim of the study: The present study was designed to investigate the molecular weight (MW), chemical composition and effect of polysaccharide (CS-PS), from the fruiting bodies of cultured Cordyceps sinensis, on immune function and anti-oxidation activity of BALB/c mice exposed to Co-60.

Materials and methods: The MW of CS-PS was determined by gel-filtration. The chemical composition of CS-PS was tested by using gas chromatography-mass spectrophotometer (GC-MS). Mice were administered CS-PS with doses of 50, 100 or 200 mg/kg body weight, then exposed to Co-60. The normal control group and irradiated control group were also used. Four days later, lymphocyte proliferation, activity of macrophage phagocytosis, delayed type hypersensitivity (DTH), concentration of malondialdehyde (MDA), total-superoxide dismutase (SOD) enzyme activity, and cytokine expression in serum from the mice were tested.

Results: The average molecular weight of CP-PS was 12 kD. The polysaccharide was composed of mannose, rhamnose, arabinose, xylose, glucose and galactose. Lymphocyte proliferation, the activity of macrophage phagocytosis, DTH and total-SOD enzyme activity in the CS-PS groups were significantly enhanced compared to the irradiated control group. Lipid peroxidation level was significantly reduced in the CS-PS groups compared to the irradiated control group. Levels of cytokine IL-4, IL-5 and IL-17 are also affected in the CS-PS groups compared to the irradiated control group.

Conclusions: CS-PS, a heteropolysaccharide, enhances immunity activity in mice treated by ionizing radiation, through reducing oxidative injury and modulating the secretion of cytokine IL-4, IL-5 and IL-17. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
资助者Nutrition and Food Hygiene Department, Peking University ; Nutrition and Food Hygiene Department, Peking University
WOS记录号WOS:000298460700043
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60997
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jiali,Yu, Yongchao,Zhang, Zhaofeng,et al. Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to Co-60[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2011,11(12):2251-2257.
APA Zhang, Jiali,Yu, Yongchao,Zhang, Zhaofeng,Ding, Ye,Dai, Xiaogian,&Li, Yong.(2011).Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to Co-60.INTERNATIONAL IMMUNOPHARMACOLOGY,11(12),2251-2257.
MLA Zhang, Jiali,et al."Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to Co-60".INTERNATIONAL IMMUNOPHARMACOLOGY 11.12(2011):2251-2257.
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