北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Changes of brain neuropeptide Y and its receptors in rats with flurazepam tolerance and dependence
作者: Zhang, LP; Wang, L
关键词: benzodiazepines ; neuropeptide Y ; flurazepam
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2005-11-01
DOI: 10.1111/j.1745-7254.2005.00179.x
卷: 26, 期:11, 页:1290-1296
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CHRONIC BENZODIAZEPINE TREATMENT ; INHIBITION ; EXPRESSION ; WITHDRAWAL ; LORAZEPAM ; DIAZEPAM ; CA1
英文摘要:

Aim: Anticonvulsant tolerance and dependence are two obstacles that restrict the clinical use of benzodiazepines (BDZ). In order to explore the mechanism of these two adverse reactions, changes of neuropeptide Y (NPY) and its receptors in the hippocampus of rat models, in relation to flurazepam (FZP, a member of BDZ) tolerance and dependence, were investigated. Methods: The mRNA of preproNPY and its receptors (Y-1, Y-2, and Y-5) in the hippocampus were determined by competitive RT-PCR, and the distribution of NPY in the hippocampus was examined by immunohistochemistry. Results: A decrease of preproNPY mRNA in the hippocampus was found in tolerant and dependent rats. The level of preproNPY mRNA in the hippocampus was reversely correlated with the degree of tolerance and dependence, measured by the threshold of pentylenetetrazol-induced seizures. Immunohistochemistry indicated a decrease of NPY-immunoreactive material in neurons of the CA1, CA3, and dentate gyrus regions of both tolerant and dependent rats. The mRNA of NPY receptors Y-1 and Y-5 decreased in tolerant rats but did not change in dependent rats. The mRNA of NPY receptor Y-2 increased in tolerant rats but decreased in dependent rats. Conclusion: A decrease of NPY in the hippocampus might be involved in anticonvulsant tolerance and dependence following long-term treatment with FZP. Y-1, Y-2, and Y-5 mRNA were also altered in FZP tolerance and dependence.

语种: 英语
WOS记录号: WOS:000233209800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61001
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, LP,Wang, L. Changes of brain neuropeptide Y and its receptors in rats with flurazepam tolerance and dependence[J]. ACTA PHARMACOLOGICA SINICA,2005,26(11):1290-1296.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, LP]'s Articles
[Wang, L]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, LP]‘s Articles
[Wang, L]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace