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Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers
Yin, Xiaoying1; Liu, Qingshan2; Ma, Xingxia1; Zhou, Xudong3; Zhao, Mingbo3; Tu, Pengfei3
关键词Molecularly imprinted polymer Sesquiterpene lactones Selective adsorption performance Molecular structure Variable-temperature H-1 NMR spectroscopy
刊名JOURNAL OF CHROMATOGRAPHY A
2014-08-08
DOI10.1016/j.chroma.2014.05.043
1354页:9-17
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
资助者National Natural Science Foundation of China ; Education Research Project of Science and Technology Foundation, Jiangxi Province, PR China ; Jiangxi Science and Technology ; National Natural Science Foundation of China ; Education Research Project of Science and Technology Foundation, Jiangxi Province, PR China ; Jiangxi Science and Technology
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SOLID-PHASE EXTRACTION ; AQUEOUS-SOLUTION ; RECOGNITION ; SURFACE ; CHROMATOGRAPHY ; ENRICHMENT ; RECEPTOR ; PROTEIN ; SAMPLES ; WATER
英文摘要

We preliminarily report that the structure of template molecules and target components correlates with the selective adsorption performance of molecularly imprinted polymer (MIPs) in sesquiterpene lactones. Template molecules involved three categories of sesquiterpene lactones with distinct ring systems: 5-mem lactone ring atractylenolide HI, 7-mem lactone ring dehydrocostus lactone, and 10-mem lactone ring costunolide lactone, of which the conformations were verified by variable-temperature H-1 NMR spectroscopy. Reciprocal MIPs were prepared by precipitation polymerization and employed as selective sorbents in the columns of solid phase extraction (SPE). These columns were further used for enriching the mixed adsorption solution of sesquiterpene lactone ingredients and reference components. Finally, the extract of RadixAucklandiae, a Chinese medicine herb, was used to verify the efficiency of this method. Our results demonstrate that the steric conformational stability of molecules is associated with the selective adsorption of their corresponding MIPs. We have further observed that the maximum adsorption capacity occurs when the target molecule conformation is consistent with that of the template molecule. The addition of more hydrophilic groups correlates with weaker adsorption of MIPs. Our findings provide important information to help guide the selection of appropriate template molecules for synthesis of MIPs with specific adsorption. (C) 2014 Published by Elsevier B.V.

语种英语
所属项目编号81260690 ; 81173657 ; GJJ13618 ; 20111BBG70004-2
资助者National Natural Science Foundation of China ; Education Research Project of Science and Technology Foundation, Jiangxi Province, PR China ; Jiangxi Science and Technology ; National Natural Science Foundation of China ; Education Research Project of Science and Technology Foundation, Jiangxi Province, PR China ; Jiangxi Science and Technology
WOS记录号WOS:000339144000002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61002
专题北京大学药学院
作者单位1.Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Peoples R China
2.Minzu Univ China, Natl Res Ctr Chinese Minor Med, Beijing 100081, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yin, Xiaoying,Liu, Qingshan,Ma, Xingxia,et al. Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1354:9-17.
APA Yin, Xiaoying,Liu, Qingshan,Ma, Xingxia,Zhou, Xudong,Zhao, Mingbo,&Tu, Pengfei.(2014).Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers.JOURNAL OF CHROMATOGRAPHY A,1354,9-17.
MLA Yin, Xiaoying,et al."Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers".JOURNAL OF CHROMATOGRAPHY A 1354(2014):9-17.
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