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The timing of acid-induced increase in saliva secretion in transplanted submandibular glands
Liu, X. J.1; Li, M.2; Su, J. Z.1; Xie, Z.3; Yu, G. Y.1
关键词keratoconjunctivitis sicca submandibular gland transplantation reinnervation scintigraphy Schirmer test
刊名INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2015-08-01
DOI10.1016/j.ijom.2015.01.003
44期:8页:1041-1047
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]SEVERE KERATOCONJUNCTIVITIS SICCA ; MICROVASCULAR AUTOLOGOUS TRANSPLANTATION ; PERMEABILITY ; SCINTIGRAPHY
英文摘要

The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS); Tc-99m scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On Tc-99m scintigraphy, no decline was detected on the dynamic time-activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at >= 6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur.

语种英语
WOS记录号WOS:000358627000018
项目编号81070847 ; 81271161 ; 20120001110045 ; 7132201 ; PKUSS20110102
资助机构National Natural Science Foundation of China ; Ministry of Education ; Beijing Natural Science Foundation ; Peking University School of Stomatology
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61005
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Nucl Med, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Global Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, X. J.,Li, M.,Su, J. Z.,et al. The timing of acid-induced increase in saliva secretion in transplanted submandibular glands[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2015,44(8):1041-1047.
APA Liu, X. J.,Li, M.,Su, J. Z.,Xie, Z.,&Yu, G. Y..(2015).The timing of acid-induced increase in saliva secretion in transplanted submandibular glands.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,44(8),1041-1047.
MLA Liu, X. J.,et al."The timing of acid-induced increase in saliva secretion in transplanted submandibular glands".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 44.8(2015):1041-1047.
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