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学科主题: 公共卫生
题名:
Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
作者: Zhang, Rui1; Zhao, Liancheng3,4; Liang, Lirong5; Xie, Gaoqiang2; Wu, Yangfeng1,2,6
关键词: Dyslipidemia ; Lipid-lowering treatment ; Goal attainment ; Gender disparity ; Patient
刊名: LIPIDS IN HEALTH AND DISEASE
发表日期: 2012-05-29
DOI: 10.1186/1476-511X-11-59
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
研究领域[WOS]: Biochemistry & Molecular Biology ; Nutrition & Dietetics
关键词[WOS]: HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA ; APOLIPOPROTEIN-E POLYMORPHISM ; PROJECT L-TAP ; CARDIOVASCULAR-DISEASE ; POSTMENOPAUSAL WOMEN ; LOVASTATIN TREATMENT ; MULTICENTER-SURVEY ; HEART-DISEASE ; MANAGED CARE ; E GENOTYPE
英文摘要:

Background: The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.

Objectives: To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.

Methods: We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL-C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.

Results: A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.

Conclusions: Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.

语种: 英语
项目资助者: Merck/Schering-Plough Company, China
WOS记录号: WOS:000308435900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61011
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Clin Res Inst, Beijing 100191, Peoples R China
2.George Inst Global Hlth China, Beijing 100088, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis Control & Res, Div CVD Prevent & Control Network, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Beijing 100037, Peoples R China
6.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing 100020, Peoples R China

Recommended Citation:
Zhang, Rui,Zhao, Liancheng,Liang, Lirong,et al. Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy[J]. LIPIDS IN HEALTH AND DISEASE,2012,11.
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