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学科主题: 药学
题名:
Molecular genetic and chemical assessment of radix angelica (Danggui) in China
作者: Zhao, KJ; Dong, TTX; Tu, PF; Song, ZH; Lo, CK; Tsim, KWK
关键词: Angelica ; authentic identification ; HPLC analysis ; TCM ; 5S-rRNA spacer domains
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
发表日期: 2003-04-23
DOI: 10.1021/jf026178h
卷: 51, 期:9, 页:2576-2583
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: 5S-RIBOSOMAL-RNA SPACER DOMAIN ; IDENTIFICATION ; SEQUENCE ; DRUGS
英文摘要:

The roots of Angelica sinensis (Danggui), a traditional Chinese medicine, have been used for invigorating blood circulation for over 2000 years in China. Three common species of Angelica roots are found in Asia: A. sinensis from China, A. acutiloba from Japan, and A. gigas from Korea. By using a molecular genetic approach, the 5S-rRNA spacer domains of the three species of Angelica were amplified, and their nucleotide sequences were determined. Diversity in DNA sequences among various species was found in their 5S-rRNA spacer domains, which could serve as markers for authentic identification of Angelica roots. In chemical analyses, the main constituents of Angelica roots including ferulic acid and Z-ligustilide were determined by HPLC; roots of A. sinensis were clearly distinct in that they contained similar to10-fold higher levels of ferulic acid and Z-ligustilide as compared to roots of A. acutiloba and A. gigas. In addition, the amounts of main constituents in roots of A. sinensis varied according to different regions of cultivation and different methods of preservation. The chemical profile determined by HPLC therefore could serve as a fingerprint for quality control of Angelica roots.

语种: 英语
WOS记录号: WOS:000182335200024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61018
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Beijing Mil Med Coll PLA, Dept Pharm, Beijing 100071, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China
3.Beijing Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, KJ,Dong, TTX,Tu, PF,et al. Molecular genetic and chemical assessment of radix angelica (Danggui) in China[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2003,51(9):2576-2583.
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