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学科主题临床医学
Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis
Wang, Junfeng1,2; Guan, Zhenpeng1,2; Ge, Zigang3
关键词Disease activity PDCD5 rheumatoid arthritis TNF-alpha
刊名BIOMARKERS
2013-03-01
DOI10.3109/1354750X.2012.759277
18期:2页:155-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]GENE-EXPRESSION PROFILES ; NF-KAPPA-B ; APOPTOSIS ; PROTEIN ; BCL-2 ; CLASSIFICATION ; FIBROBLASTS ; LEUKEMIA ; CRITERIA ; FLIP
英文摘要

Context: Programmed cell death 5 (PDCD5), a novel apoptotic regulatory gene, has been reported to be associated with rheumatoid arthritis (RA) and osteoarthritis (OA), which can regulate the apoptosis of synoviocytes and chondrocytes cultured in vitro.

Objective: To study expression characteristic of PDCD5 in plasma and synovial fluid of RA patients, and analyze its correlation with tumor necrosis factor alpha (TNF-alpha) and disease activity in RA.

Methods: A total of 135 subjects were recruited into this study (44 RA patients, 46 OA patients and 45 healthy controls). PDCD5 and TNF-alpha concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.

Results: Plasma and synovial fluid PDCD5 concentrations were significantly elevated in RA patients. Pearson correlation analysis indicated that plasma and synovial fluid PDCD5 levels were inversely correlated with TNF-alpha. Moreover, plasma PDCD5 levels were also inversely correlated with C-reactive protein and erythrocyte sedimentation rate.

Conclusion: Plasma and synovial fluid PDCD5 could be useful for monitoring the activity and progression of RA, and its abnormal expression and dysfunction may be correlated to TNF-alpha in RA patients.

语种英语
WOS记录号WOS:000314976000008
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61021
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Arthrit Clin, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Res Ctr, Beijing 100044, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100044, Peoples R China
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GB/T 7714
Wang, Junfeng,Guan, Zhenpeng,Ge, Zigang. Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis[J]. BIOMARKERS,2013,18(2):155-159.
APA Wang, Junfeng,Guan, Zhenpeng,&Ge, Zigang.(2013).Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis.BIOMARKERS,18(2),155-159.
MLA Wang, Junfeng,et al."Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis".BIOMARKERS 18.2(2013):155-159.
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