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ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice
Gao, Yan-Xiang1; Yu, Chang-An2; Lu, Jian-Hua3; Gao, Hong-Mei3; Li, Geng2; Kong, Wei4; Zheng, Jingang1
关键词ADAMTS-7 Angiotensin II Renal injury Early stage Inflammatory Elderly
刊名KIDNEY & BLOOD PRESSURE RESEARCH
2013
DOI10.1159/000355758
38期:1页:121-131
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; MUSCLE-CELL MIGRATION ; HYPERTENSION ; ATHEROSCLEROSIS ; ACTIVATION
英文摘要

Background/Aims: We investigated the recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), and matrix metalloproteinases (MMPs) as inflammatory mediators in inflammatory kidney damage by studying ADAMTS-1, -4, and -7 and MMP-9 expression in elderly mouse kidneys after angiotensin II (Ang II) administration. Methods: Ang II (2.5 mu g/kg/min) or norepinephrine (8.3 mu g/kg/min) was subcutaneously infused in old mice. Renal injury was assessed by hematoxylin-eosin staining, 24-h albuminuria, and immunohistochemistry to evaluate inflammatory cell markers. The mRNA and protein expression of ADAMTS-1, -4, and -7 and MMP-9 were determined using real-time PCR, Western blot, and immunohistochemistry 3 days after Ang II or norepinephrine administration. Results: Elderly mice in the Ang II group developed hypertension and pathological kidney damage. The mRNA and protein levels of ADAMTS-7 in the Ang II group were 3.3 +/- 1.1 (P = 0.019) and 1.6 +/- 0.1 (P = 0.047) vs. 1.0 +/- 0.1 and 1.0 +/- 0.1 in the control group on day 3. In contrast, treatment with the hypertensive agent norepinephrine did not lead to obvious renal damage or an increase in renal ADAMTS-7 expression. Conclusions: Renal ADAMTS-7 expression was induced by Ang II in elderly mice. The overexpression of ADATMTS-7 might contribute to early inflammatory kidney damage associated with aging. Copyright (c) 2014 S. Karger AG, Basel

语种英语
WOS记录号WOS:000334181300013
项目编号81170287 ; 30770865
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61022
专题北京大学基础医学院
作者单位1.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China
3.China Japan Friendship Hosp, Dept Nephrol, Beijing 100029, Peoples R China
4.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China
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GB/T 7714
Gao, Yan-Xiang,Yu, Chang-An,Lu, Jian-Hua,et al. ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice[J]. KIDNEY & BLOOD PRESSURE RESEARCH,2013,38(1):121-131.
APA Gao, Yan-Xiang.,Yu, Chang-An.,Lu, Jian-Hua.,Gao, Hong-Mei.,Li, Geng.,...&Zheng, Jingang.(2013).ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice.KIDNEY & BLOOD PRESSURE RESEARCH,38(1),121-131.
MLA Gao, Yan-Xiang,et al."ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice".KIDNEY & BLOOD PRESSURE RESEARCH 38.1(2013):121-131.
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