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学科主题: 药学
题名:
A fructan, from radix ophiopogonis, stimulates the proliferation of cultured lymphocytes: Structural and functional analyses
作者: Wu, Xiangmei; Dai, Hui; Huang, Lixin; Gao, Xiaoming; Tsim, Karl W. K.; Tu, Pengfei
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2006-09-22
DOI: 10.1021/np060033d
卷: 69, 期:9, 页:1257-1260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: ATOMIC-FORCE MICROSCOPY ; SUCROSE ; POLYSACCHARIDE ; POLYFRUCTAN ; METHYLATION ; SPECTRA ; CONIDIA ; INULIN ; ROOTS ; LEVAN
英文摘要:

A fructan, Opaw-2, with molecular mass of about 14 kDa, was isolated from the tuberous roots of Ophiopogon japonicus. Opaw-2 comprises fructose and glucose with a molar ratio of 30: 1. Linkage and NMR analyses indicated that Opaw-2 has a backbone structure of beta-(1-->2)-Fruf and beta-(2-->6)-Fruf residues that branches at O-6 of beta-(1-->2)-Fruf residues with alpha-1-linkage to the Glcp residues and terminates with Fruf residues. In cultured lymphocytes, the application of Opaw-2 significantly stimulated the proliferation of lymphocytes in a dose-dependent manner. By using atomic force microscopy, Opaw-2 showed a morphological change from globular to helical fibrous shape at increasing concentrations.

语种: 英语
WOS记录号: WOS:000240677700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61024
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Modern Res Ctr Tradit Chinese Med, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Med Sci, Beijing 100871, Peoples R China
3.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wu, Xiangmei,Dai, Hui,Huang, Lixin,et al. A fructan, from radix ophiopogonis, stimulates the proliferation of cultured lymphocytes: Structural and functional analyses[J]. JOURNAL OF NATURAL PRODUCTS,2006,69(9):1257-1260.
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