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学科主题: 临床医学
题名:
Estrogen Receptor alpha Induces Prosurvival Autophagy in Papillary Thyroid Cancer via Stimulating Reactive Oxygen Species and Extracellular Signal Regulated Kinases
作者: Fan, Dahua1; Liu, Shirley Y. W.2; van Hasselt, C. Andrew1; Vlantis, Alexander C.1; Ng, Enders K. W.2; Zhang, Haitao4; Dong, Yujuan2; Ng, Siu Kwan1; Chu, Ryan1; Chan, Amy B. W.3; Du, Jing5; Wei, Wei5; Liu, Xiaoling5; Liu, Zhimin6; Xing, Mingzhao7; Chen, George G.2
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2015-04-01
DOI: 10.1210/jc.2014-3257
卷: 100, 期:4, 页:E561-E571
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; CELL-SURVIVAL ; GROWTH ; ACTIVATION ; MECHANISMS ; EXPRESSION ; INDUCTION ; PATTERNS ; THERAPY ; TARGET
英文摘要:

Context: The incidence of papillary thyroid cancer (PTC) shows a predominance in females, with a male: female ratio of 1: 3, and none of the known risk factors are associated with gender difference. Increasing evidence indicates a role of estrogen in thyroid tumorigenesis, but the mechanism involved remains largely unknown.

Objective: This study aimed to assess the contribution of autophagy to estrogen receptor alpha (ER alpha)-mediated growth of PTC.

Design: The expression of ER alpha in thyroid tissue of patients with PTC tissues was analyzed. Cell viability, proliferation, and apoptosis were evaluated after chemical and genetic inhibition of autophagy. Autophagy in PTC cell lines BCPAP and BCPAP-ER alpha was assessed.

Results: ER alpha expression was increased in PTC tissues compared with the adjacent nontumor tissues. Estrogen induced autophagy in an ER alpha-dependent manner. Autophagy induced by estrogen/ER alpha is associated with generation of reactive oxygen species, activation of ERK1/2, and the survival/growth of PTC cells. Chemical and genetic inhibition of autophagy dramatically decreased tumor cell survival and promoted apoptosis, confirming the positive role of autophagy in the growth of PTC.

Conclusions: ER alpha contributes to the growth of PTC by enhancing an important prosurvival catabolic process, autophagy, in PTC cells. The inhibition of autophagy promotes apoptosis, implicating a novel strategy for the treatment of ER alpha-positive PTC.

语种: 英语
所属项目编号: 2012.1.016
项目资助者: Chinese University of Hong Kong Direct Grant
WOS记录号: WOS:000353361500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61025
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
4.Guangdong Med Coll, Dept Biochem & Mol Biol, Zhanjiang 524023, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
6.Chongqing Med Univ, Fac Basic Med Sci, Dept Biochem & Mol Biol, Chongqing 40016, Peoples R China
7.Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Baltimore, MD 21218 USA

Recommended Citation:
Fan, Dahua,Liu, Shirley Y. W.,van Hasselt, C. Andrew,et al. Estrogen Receptor alpha Induces Prosurvival Autophagy in Papillary Thyroid Cancer via Stimulating Reactive Oxygen Species and Extracellular Signal Regulated Kinases[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2015,100(4):E561-E571.
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