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Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center
Li, Zhi-Ying1,2; Chang, Dong-Yuan1,2; Zhao, Ming-Hui1,2; Chen, Min1,2
刊名ARTHRITIS & RHEUMATOLOGY
2014-07-01
DOI10.1002/art.38621
66期:7页:1920-1926
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ANCA-ASSOCIATED VASCULITIS ; SMALL-VESSEL VASCULITIS ; RANDOMIZED-TRIAL ; WEGENERS-GRANULOMATOSIS ; MICROSCOPIC POLYANGIITIS ; RENAL VASCULITIS ; GLOMERULONEPHRITIS ; CYCLOPHOSPHAMIDE ; REMISSION ; THERAPY
英文摘要

Objective. Treatment resistance and relapse in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are major challenges for physicians. The aim of this study was to assess the risk factors for treatment resistance and relapse in a single-center cohort of Chinese patients with AAV.

Methods. Four hundred thirty-nine consecutive patients with AAV were recruited for inclusion in this study. The value of various clinical and pathologic parameters for the prediction of treatment resistance and relapse was analyzed.

Results. Treatment resistance occurred in 47 (10.7%) of 439 patients and was independently associated with a higher serum creatinine level (odds ratio [OR] 1.087, 95% confidence interval [95% CI] 1.001-1.180, P = 0.047), a higher erythrocyte sedimentation rate (OR 1.009, 95% CI 1.001-1.018, P = 0.025), therapy with corticosteroids plus cyclophosphamide (OR 0.115, 95% CI 0.051-0.256, P = 0.000), and the presence of muscle pain (OR 0.249, 95% CI 0.083-0.747, P = 0.013). Relapse occurred in 128 (32.7%) of 392 patients in whom remission was achieved and was independently associated with lung involvement (hazard ratio [HR] 1.768, 95% CI 1.088-2.872, P = 0.021) and a lower serum creatinine level (HR 0.925, 95% CI 0.872-0.981, P = 0.009).

Conclusion. In Chinese patients with AAV, lung involvement and lower serum creatinine levels were independently associated with an increased risk of relapse. Elevated serum creatinine levels were associated with treatment resistance.

语种英语
WOS记录号WOS:000339092800027
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61028
专题北京大学第一临床医学院
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Zhi-Ying,Chang, Dong-Yuan,Zhao, Ming-Hui,et al. Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center[J]. ARTHRITIS & RHEUMATOLOGY,2014,66(7):1920-1926.
APA Li, Zhi-Ying,Chang, Dong-Yuan,Zhao, Ming-Hui,&Chen, Min.(2014).Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center.ARTHRITIS & RHEUMATOLOGY,66(7),1920-1926.
MLA Li, Zhi-Ying,et al."Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center".ARTHRITIS & RHEUMATOLOGY 66.7(2014):1920-1926.
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