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学科主题: 临床医学
题名:
Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center
作者: Li, Zhi-Ying1,2; Chang, Dong-Yuan1,2; Zhao, Ming-Hui1,2; Chen, Min1,2
刊名: ARTHRITIS & RHEUMATOLOGY
发表日期: 2014-07-01
DOI: 10.1002/art.38621
卷: 66, 期:7, 页:1920-1926
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ANCA-ASSOCIATED VASCULITIS ; SMALL-VESSEL VASCULITIS ; RANDOMIZED-TRIAL ; WEGENERS-GRANULOMATOSIS ; MICROSCOPIC POLYANGIITIS ; RENAL VASCULITIS ; GLOMERULONEPHRITIS ; CYCLOPHOSPHAMIDE ; REMISSION ; THERAPY
英文摘要:

Objective. Treatment resistance and relapse in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are major challenges for physicians. The aim of this study was to assess the risk factors for treatment resistance and relapse in a single-center cohort of Chinese patients with AAV.

Methods. Four hundred thirty-nine consecutive patients with AAV were recruited for inclusion in this study. The value of various clinical and pathologic parameters for the prediction of treatment resistance and relapse was analyzed.

Results. Treatment resistance occurred in 47 (10.7%) of 439 patients and was independently associated with a higher serum creatinine level (odds ratio [OR] 1.087, 95% confidence interval [95% CI] 1.001-1.180, P = 0.047), a higher erythrocyte sedimentation rate (OR 1.009, 95% CI 1.001-1.018, P = 0.025), therapy with corticosteroids plus cyclophosphamide (OR 0.115, 95% CI 0.051-0.256, P = 0.000), and the presence of muscle pain (OR 0.249, 95% CI 0.083-0.747, P = 0.013). Relapse occurred in 128 (32.7%) of 392 patients in whom remission was achieved and was independently associated with lung involvement (hazard ratio [HR] 1.768, 95% CI 1.088-2.872, P = 0.021) and a lower serum creatinine level (HR 0.925, 95% CI 0.872-0.981, P = 0.009).

Conclusion. In Chinese patients with AAV, lung involvement and lower serum creatinine levels were independently associated with an increased risk of relapse. Elevated serum creatinine levels were associated with treatment resistance.

语种: 英语
所属项目编号: 2012CB517700 ; 81321064 ; 81370829 ; 20120001110018 ; 2011BAI10B04
项目资助者: Chinese 973 Project ; National Natural Science Fund ; Research Fund for the Doctoral Program of Higher Education of China ; Ministry of Science and Technology of China, National Key Technology Research and Development Program
WOS记录号: WOS:000339092800027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61028
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Beijing 100871, Peoples R China

Recommended Citation:
Li, Zhi-Ying,Chang, Dong-Yuan,Zhao, Ming-Hui,et al. Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis A Study of 439 Cases in a Single Chinese Center[J]. ARTHRITIS & RHEUMATOLOGY,2014,66(7):1920-1926.
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