IR@PKUHSC  > 北京大学药学院
学科主题药学
PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION
Zhao, Ying-Yong1; Cheng, Xian-Long2; Wei, Feng2; Han, Xiao-Qiang3; Xiao, Xin-Yue2; Lin, Rui-Chao2
关键词2 3 5 4-tetrahydroxystilbene-2-O--D-glucoside bioavailability metabolism pharmacokinetics Polygoni multiflori UPLC-Q-TOF MS
刊名JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
2013-02-01
DOI10.1080/10826076.2012.673209
36期:6页:717-730
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
资助者National Scientific Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Shaanxi Provincial Science and Technology Department ; National Scientific Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Shaanxi Provincial Science and Technology Department
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]POLYGONUM-MULTIFLORUM THUNB ; CHRONIC-RENAL-FAILURE ; QUADRUPOLE-TIME ; STILBENE GLUCOSIDES ; INDUCED APOPTOSIS ; Q-TOF/MS ; METABONOMICS ; INFLAMMATION ; PLASMA ; CELLS
英文摘要

2,3,5,4-tetrahydroxystilbene-2-O--D-glucoside (THSG), a natural product purified from the Chinese medical herb Polygoni multiflori Radix, has been demonstrated to possess many pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, and antitumor properties. Ultra-performance liquid chromatographytime-of-flight mass spectrometry (UPLC-Q-TOF/MS) and high-performance liquid chromatography-ultraviolet detection (HPLC-UV) methods were developed for the pharmacokinetics, bioavailability, absorption, and metabolism studies of THSG in rats following a single intravenous or oral administration. The metabolites (M1 and M2) were identified in plasma by UPLC-Q-TOF/MS. The concentrations of the THSG in rat plasma, and bile, urine, or feces samples were determined by HPLC-UV. The results show THSG was rapidly absorbed within 30min in plasma. Absolute bioavailability of THSG was 40%. Total recovery of unchanged THSG within 24hr were low (0.041% in bile, 0.06% in feces), whereas the amount of unchanged THSG excreted in the urine within 24hr was lower than LLOQ.

语种英语
所属项目编号81001622 ; 81073029 ; 2011ZX09401-308-034 ; 2011K12-69
资助者National Scientific Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Shaanxi Provincial Science and Technology Department ; National Scientific Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Shaanxi Provincial Science and Technology Department
WOS记录号WOS:000315350900004
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61030
Collection北京大学药学院
作者单位1.NW Univ Xian, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Shaanxi, Peoples R China
2.State Food & Drug Adm, Natl Inst Food & Drug Control, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Ying-Yong,Cheng, Xian-Long,Wei, Feng,et al. PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2013,36(6):717-730.
APA Zhao, Ying-Yong,Cheng, Xian-Long,Wei, Feng,Han, Xiao-Qiang,Xiao, Xin-Yue,&Lin, Rui-Chao.(2013).PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,36(6),717-730.
MLA Zhao, Ying-Yong,et al."PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 36.6(2013):717-730.
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