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学科主题: 药学
题名:
PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION
作者: Zhao, Ying-Yong1; Cheng, Xian-Long2; Wei, Feng2; Han, Xiao-Qiang3; Xiao, Xin-Yue2; Lin, Rui-Chao2
关键词: 2 ; 3 ; 5 ; 4-tetrahydroxystilbene-2-O--D-glucoside ; bioavailability ; metabolism ; pharmacokinetics ; Polygoni multiflori ; UPLC-Q-TOF ; MS
刊名: JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
发表日期: 2013-02-01
DOI: 10.1080/10826076.2012.673209
卷: 36, 期:6, 页:717-730
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: POLYGONUM-MULTIFLORUM THUNB ; CHRONIC-RENAL-FAILURE ; QUADRUPOLE-TIME ; STILBENE GLUCOSIDES ; INDUCED APOPTOSIS ; Q-TOF/MS ; METABONOMICS ; INFLAMMATION ; PLASMA ; CELLS
英文摘要:

2,3,5,4-tetrahydroxystilbene-2-O--D-glucoside (THSG), a natural product purified from the Chinese medical herb Polygoni multiflori Radix, has been demonstrated to possess many pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, and antitumor properties. Ultra-performance liquid chromatographytime-of-flight mass spectrometry (UPLC-Q-TOF/MS) and high-performance liquid chromatography-ultraviolet detection (HPLC-UV) methods were developed for the pharmacokinetics, bioavailability, absorption, and metabolism studies of THSG in rats following a single intravenous or oral administration. The metabolites (M1 and M2) were identified in plasma by UPLC-Q-TOF/MS. The concentrations of the THSG in rat plasma, and bile, urine, or feces samples were determined by HPLC-UV. The results show THSG was rapidly absorbed within 30min in plasma. Absolute bioavailability of THSG was 40%. Total recovery of unchanged THSG within 24hr were low (0.041% in bile, 0.06% in feces), whereas the amount of unchanged THSG excreted in the urine within 24hr was lower than LLOQ.

语种: 英语
所属项目编号: 81001622 ; 81073029 ; 2011ZX09401-308-034 ; 2011K12-69
项目资助者: National Scientific Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Shaanxi Provincial Science and Technology Department
WOS记录号: WOS:000315350900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61030
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.NW Univ Xian, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Shaanxi, Peoples R China
2.State Food & Drug Adm, Natl Inst Food & Drug Control, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Ying-Yong,Cheng, Xian-Long,Wei, Feng,et al. PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-beta-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHYQUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2013,36(6):717-730.
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