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学科主题临床医学
Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China
Liu, Mengfei; He, Zhonghu; Zhang, Chanyuan; Liu, Fangfang; Liu, Ying; Li, Jingjing; Xu, Zhongyao; Wang, Qiyan; Hang, Dong; Shen, Na; Pan, Yaqi; Guo, Chuanhai; Cai, Hong; Ke, Yang
刊名SCIENTIFIC REPORTS
2015-07-23
DOI10.1038/srep10986
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HETEROSEXUAL COUPLES ; VIRAL LOAD ; CERVICAL-CANCER ; WOMEN ; MEN ; DNA ; CONCORDANCE ; CARCINOMA ; BEHAVIOR
英文摘要

HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.

语种英语
WOS记录号WOS:000358355300001
项目编号30930102 ; 81473033 ; 2011CB504300 ; 2012CB910800 ; 2012AA02A209 ; 2012AA022502 ; 201202014 ; 200902002 ; 7100001
资助机构Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; "863" Key Projects of National Ministry of Science and Technology Grant ; Charity Project of the National Ministry of Health ; Natural Science Foundation of Beijing
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61035
专题北京大学临床肿瘤学院_遗传学研究室
北京大学第二临床医学院_病理科
作者单位Peking Univ, Key Lab Carcinogenesis & Translat Res, Genet Lab, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Liu, Mengfei,He, Zhonghu,Zhang, Chanyuan,et al. Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China[J]. SCIENTIFIC REPORTS,2015,5.
APA Liu, Mengfei.,He, Zhonghu.,Zhang, Chanyuan.,Liu, Fangfang.,Liu, Ying.,...&Ke, Yang.(2015).Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China.SCIENTIFIC REPORTS,5.
MLA Liu, Mengfei,et al."Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China".SCIENTIFIC REPORTS 5(2015).
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