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学科主题: 临床医学
题名:
Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China
作者: Liu, Mengfei; He, Zhonghu; Zhang, Chanyuan; Liu, Fangfang; Liu, Ying; Li, Jingjing; Xu, Zhongyao; Wang, Qiyan; Hang, Dong; Shen, Na; Pan, Yaqi; Guo, Chuanhai; Cai, Hong; Ke, Yang
刊名: SCIENTIFIC REPORTS
发表日期: 2015-07-23
DOI: 10.1038/srep10986
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HETEROSEXUAL COUPLES ; VIRAL LOAD ; CERVICAL-CANCER ; WOMEN ; MEN ; DNA ; CONCORDANCE ; CARCINOMA ; BEHAVIOR
英文摘要:

HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.

语种: 英语
所属项目编号: 30930102 ; 81473033 ; 2011CB504300 ; 2012CB910800 ; 2012AA02A209 ; 2012AA022502 ; 201202014 ; 200902002 ; 7100001
项目资助者: Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; "863" Key Projects of National Ministry of Science and Technology Grant ; Charity Project of the National Ministry of Health ; Natural Science Foundation of Beijing
WOS记录号: WOS:000358355300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61035
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: Peking Univ, Key Lab Carcinogenesis & Translat Res, Genet Lab, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Liu, Mengfei,He, Zhonghu,Zhang, Chanyuan,et al. Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China[J]. SCIENTIFIC REPORTS,2015,5.
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