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学科主题临床医学
A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis
Lv, Yang1; Li, Ailing2; Zhou, Fang1; Pan, Xiaoyu3; Liang, Fuxin2; Qu, Xiaozhong4; Qiu, Dong2; Yang, Zhenzhong2
关键词PMMA bone cement phase-change microcapsule thermal necrosis setting time compressive strength modulus
刊名ACS APPLIED MATERIALS & INTERFACES
2015-06-03
DOI10.1021/acsami.5b01447
7期:21页:11280-11285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]VERTEBRAL FRACTURE ; MECHANICAL PERFORMANCE ; TEMPERATURE EVALUATION ; SETTING PROPERTIES ; IN-VITRO ; AUGMENTATION ; SIZE ; VERTEBROPLASTY ; INTERFACE ; MODULUS
英文摘要

Percutaneous vertebroplasty (VP) and balloon kyphoplasty (BKP) are now widely used to treat patients who suffer painful vertebral compression fractures. In each of these treatments, a bone cement paste is injected into the fractured vertebral body/bodies, and the cement of choice is a poly(methyl methacrylate) (PMMA) bone cement. One drawback of this cement is the very high exothermic temperature, which, it has been suggested, causes thermal necrosis of surrounding tissue. In the present work, we prepared novel composite PMMA bone cement where microcapsules containing a phase change material (paraffin) (PCMc) were mixed with the powder of the cement. A PCM absorbs generated heat and, as such, its presence in the cement may lead to reduction in thermal necrosis. We determined a number of properties of the composite cement. Compared to the values for a control cement (a commercially available PMMA cement used in VP and BKP), each composite cement was found to have significantly lower maximum exothermic temperature, increased setting time, significantly lower compressive strength, significantly lower compressive modulus, comparable biocompatibility, and significantly smaller thermal necrosis zone. Composite cement containing 20% PCMc may be suitable for use in VP and BKP and thus deserves further evaluation.

语种英语
WOS记录号WOS:000355891700029
项目编号2012CB933200 ; 2013DFG52300 ; 51173193
资助机构MOST ; NSFC
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61037
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Soochow Univ, Coll Med, Suzhou 215123, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Lv, Yang,Li, Ailing,Zhou, Fang,et al. A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(21):11280-11285.
APA Lv, Yang.,Li, Ailing.,Zhou, Fang.,Pan, Xiaoyu.,Liang, Fuxin.,...&Yang, Zhenzhong.(2015).A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis.ACS APPLIED MATERIALS & INTERFACES,7(21),11280-11285.
MLA Lv, Yang,et al."A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis".ACS APPLIED MATERIALS & INTERFACES 7.21(2015):11280-11285.
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