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学科主题: 临床医学
题名:
A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis
作者: Lv, Yang1; Li, Ailing2; Zhou, Fang1; Pan, Xiaoyu3; Liang, Fuxin2; Qu, Xiaozhong4; Qiu, Dong2; Yang, Zhenzhong2
关键词: PMMA bone cement ; phase-change microcapsule ; thermal necrosis ; setting time ; compressive strength ; modulus
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015-06-03
DOI: 10.1021/acsami.5b01447
卷: 7, 期:21, 页:11280-11285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: VERTEBRAL FRACTURE ; MECHANICAL PERFORMANCE ; TEMPERATURE EVALUATION ; SETTING PROPERTIES ; IN-VITRO ; AUGMENTATION ; SIZE ; VERTEBROPLASTY ; INTERFACE ; MODULUS
英文摘要:

Percutaneous vertebroplasty (VP) and balloon kyphoplasty (BKP) are now widely used to treat patients who suffer painful vertebral compression fractures. In each of these treatments, a bone cement paste is injected into the fractured vertebral body/bodies, and the cement of choice is a poly(methyl methacrylate) (PMMA) bone cement. One drawback of this cement is the very high exothermic temperature, which, it has been suggested, causes thermal necrosis of surrounding tissue. In the present work, we prepared novel composite PMMA bone cement where microcapsules containing a phase change material (paraffin) (PCMc) were mixed with the powder of the cement. A PCM absorbs generated heat and, as such, its presence in the cement may lead to reduction in thermal necrosis. We determined a number of properties of the composite cement. Compared to the values for a control cement (a commercially available PMMA cement used in VP and BKP), each composite cement was found to have significantly lower maximum exothermic temperature, increased setting time, significantly lower compressive strength, significantly lower compressive modulus, comparable biocompatibility, and significantly smaller thermal necrosis zone. Composite cement containing 20% PCMc may be suitable for use in VP and BKP and thus deserves further evaluation.

语种: 英语
所属项目编号: 2012CB933200 ; 2013DFG52300 ; 51173193
项目资助者: MOST ; NSFC
WOS记录号: WOS:000355891700029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61037
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Soochow Univ, Coll Med, Suzhou 215123, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China

Recommended Citation:
Lv, Yang,Li, Ailing,Zhou, Fang,et al. A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(21):11280-11285.
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