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学科主题: 精神卫生
题名:
Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder
作者: Wang, B; Wang, YF; Zhou, RL; Li, J; Qian, QJ; Yang, L; Guan, LL; Faraone, SV
关键词: attention deficit/hyperactivity disorder ; ADRA2A gene ; symptom ; transmission disequilibrium ; haplotype
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2006-03-05
DOI: 10.1002/ajmg.b.30258
卷: 141B, 期:2, 页:130-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; CORTICAL COGNITIVE FUNCTION ; ADHD ; LINKAGE ; POLYMORPHISMS ; ATOMOXETINE ; MEMORY ; ADULTS
英文摘要:

A dysfunction of the central noradrenergic system has long been suggested to be involved in attention-deficit/hyperactivity disorder (ADHD). Pharmacological evidence from animal studies and clinical practice has identified the alpha-2A adrenergic receptor gene (ADRA2A) as a candidate gene in ADHD. Some findings from Caucasian populations seem to support a role for this gene in ADHD. The current study first examined the association of the ADRA2A MspI and DraI polymorphisms with ADHD in the Han Chinese population, which differs quite substantially from the Caucasian population in the frequencies of alleles at these polymorphisms. No biased transmission of alleles of either polymorphism was observed using transmission disequilibrium. test (TDT) analysis in a sample of 268 nuclear families with an ADHD proband; however, haplotype analysis only identified a trend toward over-transmission of the M/C haplotype to probands with the combined subtype of ADHD (chi(2) = 3.233, P = 0.072). The mm genotype of the MspI polymorphism was also marginally related (P = 0.051) to lower ADHD symptom scores in a sample of 559 Chinese children with ADHD, which is inconsistent with data from Caucasian samples. Our results provide weak evidence for a possible role of ADRA2A in ADHD symptom expression. (C) 2006 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000235142200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61038
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA

Recommended Citation:
Wang, B,Wang, YF,Zhou, RL,et al. Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(2):130-134.
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