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学科主题: 临床医学
题名:
Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register study
作者: Wei, Jade W.1,2; Huang, Yining3; Wang, Ji-Guang4; Liu, Ming5; Wong, Lawrence K. S.6; Huang, Qifang4; Wu, Li′ e(7); Heeley, Emma L.1,2; Arima, Hisatomi1,2; Anderson, Craig S.4; ChinaQUEST Investigators
刊名: BMC NEUROLOGY
发表日期: 2011-01-30
DOI: 10.1186/1471-2377-11-16
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBRAL INFARCTION ; ACUTE STROKE ; HEALTH ; SUBTYPES ; CLASSIFICATION ; GUIDELINES ; TRIAL
英文摘要:

Background: We aimed to examine current practice of the management and secondary prevention of intracerebral haemorrhage (ICH) in China where the disease is more common than in Western populations.

Methods: Data on baseline characteristics, management in-hospital and post-stroke, and outcome of ICH patients are from the ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) study, a multi-centre, prospective, 62 hospital registry in China during 2006-07.

Results: Nearly all ICH patients (n = 1572) received an intravenous haemodiluting agent such as mannitol (96%) or a neuroprotectant (72%), and there was high use of intravenous traditional Chinese medicine (TCM) (42%). Neurosurgery was undertaken in 137 (9%) patients; being overweight, having a low Glasgow Coma Scale (GCS) score on admission, and Total Anterior Circulation Syndrome (TACS) clinical pattern on admission, were the only baseline factors associated with this intervention in multivariate analyses. Neurosurgery was associated with nearly three times higher risk of death/disability at 3 months post-stroke (odd ratio [OR] 2.60, p < 0.001). Continuation of antihypertensives in-hospital and at 3 and 12 months post-stroke was reported in 732/935 (78%), 775/935 (83%), and 752/935 (80%) living patients with hypertension, respectively.

Conclusions: The management of ICH in China is characterised by high rates of use of intravenous haemodiluting agents, neuroprotectants, and TCM, and of antihypertensives for secondary prevention. The controversial efficacy of these therapies, coupled with the current lack of treatments of proven benefit, is a call for action for more outcomes based research in ICH.

语种: 英语
项目资助者: Macquarie Bank Foundation ; George Foundation ; AstraZeneca Pharmaceutical China ; George Institute for Global Health ; Australian Postgraduate Award
WOS记录号: WOS:000287505600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61040
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Univ Sydney, Sydney, NSW 2006, Australia
2.Affiliated Hosp 1, Baotou Med Coll, Baotou, Peoples R China
3.Royal Prince Alfred Hosp, George Inst Global Hlth, Sydney, NSW, Australia
4.Peking Univ, Dept Neurol, Hosp 1, Beijing 100871, Peoples R China
5.Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
6.Sichuan Univ, Dept Neurol, W China Hosp, Chengdu 610064, Peoples R China
7.Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wei, Jade W.,Huang, Yining,Wang, Ji-Guang,et al. Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register study[J]. BMC NEUROLOGY,2011,11.
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