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学科主题: 基础医学
题名:
Functional Vanilloid Receptor-1 in Human Submandibular Glands
作者: Ding, Q. W.2; Zhang, Y.1; Wang, Y.2; Wang, Y. N.1; Zhang, L.2; Ding, C.1; Wu, L. L.1; Yu, G. Y.2
关键词: capsaicin ; submandibular gland ; vanilloid receptor-1
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2010-07-01
DOI: 10.1177/0022034510366841
卷: 89, 期:7, 页:711-716
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: ACTIVATED ION-CHANNEL ; ACINAR-CELLS ; MICE LACKING ; CAPSAICIN RECEPTOR ; EXPRESSION ; TRPV1 ; SUBTYPE-1 ; SECRETION ; RELEASE ; CA2+
英文摘要:

Vanilloid receptor-1 (VR1) was originally found in the nervous system. Recent evidence indicates that VR1 is also expressed in various cell types. We hypothesized that VR1 exists in the human submandibular gland (SMG) and is involved in regulating salivary secretion. VR1 mRNA and protein were expressed in human SMGs and a human salivary intercalated duct cell line. VR1 was mainly located in serous acinar and ductal cells, but not in mucous acinar cells. Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane. These effects were abolished by pre-treatment with the VR1 antagonist capsazepine. Furthermore, capsaicin cream applied to the skin covering the submandibular area increased salivary secretion. These findings indicated that a functional VR1 is expressed in the human SMG and is involved in regulating salivary secretion by mediating AQP5 trafficking.

语种: 英语
所属项目编号: 30730102 ; 30700 949 ; 2007BAI18B11 ; 2005-2009
项目资助者: National Nature Science Foundation of China ; National supporting program for science and technology ; Capital Medical Development Foundation
WOS记录号: WOS:000278829300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61042
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Ding, Q. W.,Zhang, Y.,Wang, Y.,et al. Functional Vanilloid Receptor-1 in Human Submandibular Glands[J]. JOURNAL OF DENTAL RESEARCH,2010,89(7):711-716.
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