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学科主题基础医学
Functional Vanilloid Receptor-1 in Human Submandibular Glands
Ding, Q. W.2; Zhang, Y.1; Wang, Y.2; Wang, Y. N.1; Zhang, L.2; Ding, C.1; Wu, L. L.1; Yu, G. Y.2
关键词capsaicin submandibular gland vanilloid receptor-1
刊名JOURNAL OF DENTAL RESEARCH
2010-07-01
DOI10.1177/0022034510366841
89期:7页:711-716
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]ACTIVATED ION-CHANNEL ; ACINAR-CELLS ; MICE LACKING ; CAPSAICIN RECEPTOR ; EXPRESSION ; TRPV1 ; SUBTYPE-1 ; SECRETION ; RELEASE ; CA2+
英文摘要

Vanilloid receptor-1 (VR1) was originally found in the nervous system. Recent evidence indicates that VR1 is also expressed in various cell types. We hypothesized that VR1 exists in the human submandibular gland (SMG) and is involved in regulating salivary secretion. VR1 mRNA and protein were expressed in human SMGs and a human salivary intercalated duct cell line. VR1 was mainly located in serous acinar and ductal cells, but not in mucous acinar cells. Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane. These effects were abolished by pre-treatment with the VR1 antagonist capsazepine. Furthermore, capsaicin cream applied to the skin covering the submandibular area increased salivary secretion. These findings indicated that a functional VR1 is expressed in the human SMG and is involved in regulating salivary secretion by mediating AQP5 trafficking.

语种英语
WOS记录号WOS:000278829300010
项目编号30730102 ; 30700 949 ; 2007BAI18B11 ; 2005-2009
资助机构National Nature Science Foundation of China ; National supporting program for science and technology ; Capital Medical Development Foundation
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61042
专题北京大学基础医学院_心血管所
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
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GB/T 7714
Ding, Q. W.,Zhang, Y.,Wang, Y.,et al. Functional Vanilloid Receptor-1 in Human Submandibular Glands[J]. JOURNAL OF DENTAL RESEARCH,2010,89(7):711-716.
APA Ding, Q. W..,Zhang, Y..,Wang, Y..,Wang, Y. N..,Zhang, L..,...&Yu, G. Y..(2010).Functional Vanilloid Receptor-1 in Human Submandibular Glands.JOURNAL OF DENTAL RESEARCH,89(7),711-716.
MLA Ding, Q. W.,et al."Functional Vanilloid Receptor-1 in Human Submandibular Glands".JOURNAL OF DENTAL RESEARCH 89.7(2010):711-716.
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