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学科主题临床医学
Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review
Yu, Cong1; Chang, Christopher2; Zhang, Jianzhong1
关键词Lupus erythematosus Cutaneous lupus erythematosus Apoptosis Dendritic cells Treg cells Th17 cells Ultraviolet Autoantibody
刊名JOURNAL OF AUTOIMMUNITY
2013-03-01
DOI10.1016/j.jaut.2013.01.007
41期:SI页:34-45
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; PLASMACYTOID DENDRITIC CELLS ; DRUG-INDUCED LUPUS ; TNF-ALPHA ; ULTRAVIOLET-LIGHT ; SJOGRENS-SYNDROME ; NUCLEAR ANTIGENS ; SUSCEPTIBILITY GENES ; HUMAN KERATINOCYTES ; AUTOIMMUNE-DISEASE
英文摘要

Cutaneous lupus erythematosus (CLE) refers to those subtypes of lupus erythematosus (LE) that have predominantly skin manifestations. Discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), LE panniculitis (LEP) and lupus erythematosus tumidus (LET) all fall into the category of CLE. The pathogenesis of CLE is likely multifactorial. UV irradiation has been shown to induce keratinocyte apoptosis,Impaired clearance of apoptotic cells is a potential mechanism for the development of CLE. UV irradiation can also induce externalization of autoantigens such as Ro/SSA, exposing them to circulating autoantibodies." Some drugs have been associated with CLE. Possible mechanisms include stimulation of an immune response through disruption of central tolerance and altered T cell function. T17 cells may also play a role in the pathogenesis of CLE as they have been detected in skin lesions of LE. Treg cells have been found to be decreased in LE lesions, which may contribute to the breakdown of self-tolerance. Epidermal Langerhans cells are reduced in CLE while plasmacytoid DCs are increased in the lesions of CLE, suggesting that DCs may also play an important role in the pathogenesis of CLE. Type I IFN- and TNF-alpha are both upregulated in lesions of CLE. Other cytokines such as IL-6 and IL-17 are also implicated in the pathogenesis of CLE. Cellular and cytokine networks can be impacted by environmental factors and genetic variations and this can result in an increased risk of developing autoimmune diseases such as CLE. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000318331800005
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61047
专题北京大学第二临床医学院_皮科
作者单位1.Peking Univ Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
2.Thomas Jefferson Univ, Div Allergy & Immunol, Nemours AI duPont Hosp Children, Wilmington, DE 19803 USA
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GB/T 7714
Yu, Cong,Chang, Christopher,Zhang, Jianzhong. Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review[J]. JOURNAL OF AUTOIMMUNITY,2013,41(SI):34-45.
APA Yu, Cong,Chang, Christopher,&Zhang, Jianzhong.(2013).Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review.JOURNAL OF AUTOIMMUNITY,41(SI),34-45.
MLA Yu, Cong,et al."Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review".JOURNAL OF AUTOIMMUNITY 41.SI(2013):34-45.
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