北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 皮科  > 期刊论文
学科主题: 临床医学
题名:
Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review
作者: Yu, Cong1; Chang, Christopher2; Zhang, Jianzhong1
关键词: Lupus erythematosus ; Cutaneous lupus erythematosus ; Apoptosis ; Dendritic cells ; Treg cells ; Th17 cells ; Ultraviolet ; Autoantibody
刊名: JOURNAL OF AUTOIMMUNITY
发表日期: 2013-03-01
DOI: 10.1016/j.jaut.2013.01.007
卷: 41, 期:SI, 页:34-45
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; PLASMACYTOID DENDRITIC CELLS ; DRUG-INDUCED LUPUS ; TNF-ALPHA ; ULTRAVIOLET-LIGHT ; SJOGRENS-SYNDROME ; NUCLEAR ANTIGENS ; SUSCEPTIBILITY GENES ; HUMAN KERATINOCYTES ; AUTOIMMUNE-DISEASE
英文摘要:

Cutaneous lupus erythematosus (CLE) refers to those subtypes of lupus erythematosus (LE) that have predominantly skin manifestations. Discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), LE panniculitis (LEP) and lupus erythematosus tumidus (LET) all fall into the category of CLE. The pathogenesis of CLE is likely multifactorial. UV irradiation has been shown to induce keratinocyte apoptosis,Impaired clearance of apoptotic cells is a potential mechanism for the development of CLE. UV irradiation can also induce externalization of autoantigens such as Ro/SSA, exposing them to circulating autoantibodies." Some drugs have been associated with CLE. Possible mechanisms include stimulation of an immune response through disruption of central tolerance and altered T cell function. T17 cells may also play a role in the pathogenesis of CLE as they have been detected in skin lesions of LE. Treg cells have been found to be decreased in LE lesions, which may contribute to the breakdown of self-tolerance. Epidermal Langerhans cells are reduced in CLE while plasmacytoid DCs are increased in the lesions of CLE, suggesting that DCs may also play an important role in the pathogenesis of CLE. Type I IFN- and TNF-alpha are both upregulated in lesions of CLE. Other cytokines such as IL-6 and IL-17 are also implicated in the pathogenesis of CLE. Cellular and cytokine networks can be impacted by environmental factors and genetic variations and this can result in an increased risk of developing autoimmune diseases such as CLE. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81071296 ; 81271756
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000318331800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61047
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
2.Thomas Jefferson Univ, Div Allergy & Immunol, Nemours AI duPont Hosp Children, Wilmington, DE 19803 USA

Recommended Citation:
Yu, Cong,Chang, Christopher,Zhang, Jianzhong. Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review[J]. JOURNAL OF AUTOIMMUNITY,2013,41(SI):34-45.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Cong]'s Articles
[Chang, Christopher]'s Articles
[Zhang, Jianzhong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Cong]‘s Articles
[Chang, Christopher]‘s Articles
[Zhang, Jianzhong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace