IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study
Zheng, Fanfan1,2; Wang, Lifang1,2; Jia, Meixiang2; Yue, Weihua1,2; Ruan, Yan1,2; Lu, Tianlan1,2; Liu, Jing2; Li, Jun1,2; Zhang, Dai1,2
关键词DISC1 autism SNP FBAT association study
刊名BEHAVIORAL AND BRAIN FUNCTIONS
2011-05-15
DOI10.1186/1744-9081-7-14
7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
资助者National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]ADULT BRAIN ; SPECTRUM DISORDERS ; NEURITE OUTGROWTH ; MOTOR TASK ; DISRUPTED-IN-SCHIZOPHRENIA-1 ; RISK ; TWIN ; TRANSLOCATION ; PROTEIN ; CORTEX
英文摘要

Background: Disrupted-in-Schizophrenia 1 (DISC1) gene is one of the most promising candidate genes for major mental disorders. In a previous study, a Finnish group demonstrated that DISC1 polymorphisms were associated with autism and Asperger syndrome. However, the results were not replicated in Korean population. To determine whether DISC1 is associated with autism in Chinese Han population, we performed a family-based association study between DISC1 polymorphisms and autism.

Methods: We genotyped seven tag single nucleotide polymorphisms (SNPs) in DISC1, spanning 338 kb, in 367 autism trios (singleton and their biological parents) including 1,101 individuals. Single SNP association and haplotype association analysis were performed using the family-based association test (FBAT) and Haploview software.

Results: We found three SNPs showed significant associations with autism (rs4366301: G > C, Z = 2.872, p = 0.004; rs11585959: T > C, Z = 2.199, p = 0.028; rs6668845: A > G, Z = 2.326, p = 0.02). After the Bonferroni correction, SNP rs4366301, which located in the first intron of DISC1, remained significant. When haplotype were constructed with two-markers, three haplotypes displayed significant association with autism. These results were still significant after using the permutation method to obtain empirical p values.

Conclusions: Our study provided evidence that the DISC1 may be the susceptibility gene of autism. It suggested DISC1 might play a role in the pathogenesis of autism.

语种英语
所属项目编号2010CB833905 ; 30870897 ; 81071110 ; 7081005
资助者National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000291648600001
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61052
专题北京大学精神卫生研究所
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Fanfan,Wang, Lifang,Jia, Meixiang,et al. Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2011,7.
APA Zheng, Fanfan.,Wang, Lifang.,Jia, Meixiang.,Yue, Weihua.,Ruan, Yan.,...&Zhang, Dai.(2011).Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study.BEHAVIORAL AND BRAIN FUNCTIONS,7.
MLA Zheng, Fanfan,et al."Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study".BEHAVIORAL AND BRAIN FUNCTIONS 7(2011).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Fanfan]的文章
[Wang, Lifang]的文章
[Jia, Meixiang]的文章
百度学术
百度学术中相似的文章
[Zheng, Fanfan]的文章
[Wang, Lifang]的文章
[Jia, Meixiang]的文章
必应学术
必应学术中相似的文章
[Zheng, Fanfan]的文章
[Wang, Lifang]的文章
[Jia, Meixiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。